We describe a new 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU)-mediated coupling reaction to produce 2-imino benzo[e]-1,3-oxazin-4-ones from salicylic acids and anilines. Mechanistic studies support a reaction pathway in which HATU mediates carbon transfer to the initially formed salicylanilides to form in succession reactive tetramethyli...

The 2,4- and 2,5-dihydroxybenzamides (8, 9) were synthesized from their corresponding methyl esters. The structures and the spectral properties of investigated salicylic acid (1), 2,4- and 2,5-dihydroxy benzoic acids (2, 3), their methyl esters (4-6) and amides (7-9) were analyzed by means of FT-IR and one- and two-dimensional homo- and heteronuclear 1H and 13C NMR spectroscopies. Comparison of...

Introduction Diflunisal has been reported as causing acute allergic interstitial nephritis (Chan et al., 1980) resulting in acute oliguric renal failure. A case of acute renal failure due to tubulo-interstitial nephritis after 3 months of diflunisal is reported here. Recently, phenylakalonic acids with analgesic and antiinflammatory properties such as fenoprofen and naproxen have been reported ...

Salinity of soil is a major abiotic stress limiting the crop production and growth of safflower. To mitigate stress, the effects of penconazole (PEN) on the growth of safflower were studied to understand the underlying mechanisms of salt tolerance. PEN, a triazole derivative, which has both fungicidal and plant growth regulator properties, protects plants from several types of abiotic stresses....

Aloe vera belongs to the family of Asphodelaceae, oldest medicinal herb ever found and world's most common plant. It is known as Ghritkumari, used in medicine sources homeopathy, ayurvedic, allopathy. The species a good source repository chemical ingredients that shows precise range biological activities such wound healing, burn treatment, mitigating frost bite damage, defense against, lung can...

We investigated the interactions between CO2-rich fluids and Mg-silicate minerals using experiments to provide information on reaction rates and to identify potential catalysts for the reactions, and studies of natural analogues to assess the conditions that lead to massive carbonation of ultramafic rocks and thus the potential for field-scale implementation. Key findings from our exploratory w...

The contents of free phenolic acids and cinnamic acid were determined using an HPLC method in methanolic extracts from biomass of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) at different stages of organogenesis, cultured in vitro on a few variants of Murashige and Skoog (MS) medium, containing different concentrations of plant growth regulators 6-benzylaminopurine (BAP) and 1-n...

На производство пшеницы влияют стрессоры, в том числе абиотические и биотические. Современное сельскохозяйственное требует увеличения использования агрохимикатов (пестицидов удобрений) для получения здоровых культур с оптимальной пищевой ценностью высокой урожайностью, что является серьезной проблемой производстве продуктов питания. В настоящее время связи растущими опасениями рассматривается и...

Salicylic acid is a classic nonsteroidal anti-inflammatory drug. Although salicylic acid also induces mitochondrial injury, the mechanism of its antimitochondrial activity is not well understood. In this study, by using a one-step affinity purification scheme with salicylic acid-immobilized beads, ferrochelatase (FECH), a homodimeric enzyme involved in heme biosynthesis in mitochondria, was ide...