Salmonella enterica subspecies enterica serotype Typhi (S. Typhi) is the causative agent of typhoid fever that is still a major challenge for public health in developing countries. The bacterium is transmitted by faeco-oral route, through contaminated water or food. Salmonella Typhi is highly adapted to human host; the only reservoir is man. The diagnosis of typhoid becomes difficult as discrim...

Salmonella typhi is a versatile pathogen with amazing potential of infecting almost all organs of its host. Globally, the life threatening illnesses caused by Salmonella typhi have made this pathogen a serious health concern for infection control professionals. Various microbes have been found associated with intrarenal abscesses that ultimately lead to high morbidity and mortality rates. We ar...

Latar belakang: Demam tifoid disebabkan oleh bakteri Salmonella enterica reservoir typhi, juga dikenal sebagai salmonella typhi (S. typhi). Tujuan dari penelitian ini untuk mengetahui bagaimana efek penggunaan antibiotik pada pasien demam yang komplikasi dan tanpa komplikasi.
 Metode: Jenis Penelitian adalah deskriptif kualitatif, menggunakan pendekatan Cross Sectional Study. Desain Study ...

The generation of complete genome sequences provides a blueprint that facilitates the genetic characterization of pathogens and their hosts. The genome of Salmonella enterica serovar Typhi (S. Typhi) harbors ~5 million base pairs encoding some 4000 genes, of which >200 are functionally inactive. Comparison of S. Typhi isolates from around the world indicates that they are highly related (clonal...

BACKGROUND Salmonella enterica serovars Typhi and Paratyphi A are human host-restricted pathogens. Therefore, there is no small susceptible animal host that can be used to assess the virulence and safety of vaccine strains derived from these Salmonella serovars.  However, infant mice have been used to evaluate virulence and colonization by another human host-restricted pathogen, Vibrio cholerae...

Two Salmonella enterica serovar Typhi strains that express and export a truncated version of Plasmodium falciparum circumsporozoite surface protein (tCSP) fused to Salmonella serovar Typhi cytolysin A (ClyA) were constructed as a first step in the development of a preerythrocytic malaria vaccine. Synthetic codon-optimized genes (t-csp1 and t-csp2), containing immunodominant B- and T-cell epitop...

OBJECTIVES The morbidity and mortality of patients with rheumatic diseases has improved considerably following the use of biologic therapies. However, an increase in the frequency of bacterial infections has been observed in patients receiving these drugs. In the present study we aimed to establish the incidence and clinical manifestations of non-typhi Salmonella infection in a large cohort of ...

A multiplex PCR-based assay was developed for detection of Salmonella typhi and identification of other salmonella serotypes. Three primer-sets were selected from different genomic sequences, malo2-F/malo2-Ra primers from invasion gene, Parat-s/Parat-as as well as tyv-s/tyv-as primers from O-antigen gene cluster of the genus Salmonella. This method differentiated Salmonella spp., based on size ...

Enteric fever, caused by Salmonella enterica, remains an unresolved public health problem in India and antimicrobial therapy is the main mode of treatment. The objective of this study was to characterize the Salmonella enterica isolates from Kolkata with respect to their antimicrobial resistance (AMR), virulence profiles and molecular subtypes. Salmonella enterica blood isolates were collected ...

background: salmonella enterica serovar typhi, as causative agent of typhoid fever, is one of the most important endemic pathogens. non-typhoidal salmonella serovars, including typhimurium , infantis , and enteritidis are amongst the most prevalent serotypes worldwide and in developing areas such as iran. the aim of this study was to apply a uniplex pcr for rapid detection of salmonella spp., a...