anatomy of the root canal system always effects endodontic treatment outcome. mandibular premolar teeth show extreme variations in root canal morphology. first premolars usually exhibit basic one root and one canal anatomy. the occurrence of three roots in mandibular first premolar has not been commonly reported in literature. this article reports a case of successful nonsurgical endodontic man...

Background and objectives:Wild Sage(Salvia macrosiphon Boiss.) known as “Marvak” in Persian is one of the polymorphic and abundant plants of Lamiaceae. The plants whole seeds usually soaked or boiled in hot water are widely used for inflammatory ailments in folk medicine. Documents have shown that there is scant information on the chemical constituents of this...

The active ingredients of salvia (dried root of Salvia miltiorrhiza) include both lipophilic (e.g., tanshinone IIA, tanshinone I, cryptotanshinone and dihydrotanshinone I) and hydrophilic (e.g., danshensu and salvianolic acid B) constituents. The low oral bioavailability of these constituents may limit their efficacy. A solid self-microemulsifying drug delivery system (S-SMEDDS) was developed t...

in this study, the oil yield, fatty acid (fa) composition and the physicochemical and quality characteristics of salvia macrosiphon crude seed oil were determined. the main fatty acids ranked in the following order of abundance: α- linolenic acid> linoleic acid> oleic acid. the n3 /n6 fa ratio and polyunsaturated fa/ saturated fa ratio were 1.6 and 7.23, respectively. the fa composition reveale...

OBJECTIVE To investigate the differentiation of bone marrow stromal cells (BMSC) into neuron-like cells and to explore their potential use for neural transplantation. METHODS BMSC from rats and adult humans were cultured in serum-containing media. Salvia miltiorrhiza was used to induce human BMSC (hBMSC) to differentiate. BMSC were identified with immunocytochemistry. Semi-quantitative RT-PCR...