Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder, and the effects of radiotherapy on such population group are unknown. A 60-year-old male with history KSS was diagnosed locally advanced basal cell carcinoma along left inner canthus. He treated at our institution curative intent alone tolerated it well no major acute or late toxicities. There complete clinical radiological response ...

Complete heart block has a varied aetiology; commoner being ischaemia and senile degeneration of AV node. In this article we report a case of complete heart block (AV nodal) in patient of Kearns Sayre Syndrome who has incidently SA node disease also which is further rarer in this disorder.

Examination of the retinal tissues obtained at necropsy from a 14-year-old boy with Kearns-Sayre syndrome showed marked photoreceptor and pigment epithelial cell loss in the retinal periphery and around the optic nerve head. Electron microscopy of surviving retinal pigment epithelial (RPE) cells indicated a loss of apical microvilli and basal infoldings. The RPE was unusually devoid of melanoso...

To cite: Sharma AK, Jain N, Kharwar RB, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016216500 DESCRIPTION We describe the images of a 27-year-old man presenting with recurrent syncope due to complete heart block (figure 1). The patient, on further examination, showed ophthalmoplegia, bilateral ptosis (figure 2) and pigmentary retinopathy (figure 3). Ke...

I this issue of PNAS Miao, Hodgson, and Sayre (1) validate a method of three-dimensional structure determination for individual biological macromolecules. Their proposal, based on suggestions by Hajdu and colleagues (2), is supported by careful computer simulation using plausible assumptions, and rests on recent advances in a number of related fields. In brief, they adopt the idea that femtosec...

ment recommended are eminently practical and good. We notice that the author speaks with high approval of Sayre's plaster-of-Paris jackets in spinal caries, and that he prefers the horizontal suspension on a hammock to the vertical method of suspension by the head and arms. We are quite of his opinion, but we do not see why he should always speak of Sayre as " Sayer." In the treatment of parapl...

PURPOSE To report the presentation of a rare case of Kearns-Sayre-like syndrome (KSS) CASE: A 14-year-old boy presented with progressive drooping of both upper eyelids for 10 years. Past history of right sided hemi-plegia and left facial nerve palsy was present. Examination (OU) showed total external ophthalmoplegia, ptosis and pigmentary retinopathy. The patient also had a short stature (heigh...