Immunotherapy with high-dose interleukin-2 (HDIL-2) is an effective treatment for patients with metastatic melanoma and renal cell carcinoma. However, it is accompanied by severe toxicity involving endothelial cell injury and induction of vascular leak syndrome (VLS). In this study, we found that resveratrol, a plant polyphenol with anti-inflammatory and anti-cancer properties, was able to prev...

INTRODUCTION Tremulous jaw movement (TJMs) in rats can be induced pharmacologically by striatal dopaminergic manipulation or electrolytic lesion of ventrolateral striatum (VLS). This tremor has neurochemical, anatomical and electromyographic (EMG) characteristics similar to those of tremor in Parkinson patients. However, the EMG characteristics of tremors generated by electrolytic lesion to the...

Vascular leak syndrome (VLS) is the dose-limiting toxicity observed in clinical trials of immunotoxins containing ricin toxin A chain (RTA). RTA itself is thought to cause VLS by damaging vascular endothelial cells, but the exact mechanism remains unclear. This is partially due to the paucity of appropriate models. To study VLS, we developed an in vitro model in which human umbilical vein-deriv...

Single crystalline metal oxide nanowires formed via a vapor-liquid-solid (VLS) route provide a platform not only for studying fundamental nanoscale properties but also for exploring novel device applications. Although the crystal phase variation of metal oxides, which exhibits a variety of physical properties, is an interesting feature compared with conventional semiconductors, it has been diff...

The purpose of this study was to determine the correlation between vocabulary learning strategies and reading comprehension, as well extent which contributed students' comprehension. correlational research design used for study. sample 68 students chosen using purposive technique. questionnaire on comprehension test were collect data Pearson Product Moment regression analysis analyze obtained d...

The thin-film vapor−liquid−solid (TF-VLS) growth technique presents a promising route for high quality, scalable, and cost-effective InP thin films for optoelectronic devices. Toward this goal, careful optimization of material properties and device performance is of utmost interest. Here, we show that exposure of polycrystalline Zn-doped TF-VLS InP to a hydrogen plasma (in the following referre...

in this study the synthesis of molybdenum oxide nano-whiskers with circular cross-section is performed. in some areas, it was observed that also some whiskers have open tips exhibiting their hollow structures. these whiskers have side dimensions ranging 2-5 μm with an average diameter in the nanometer rang. the structure suggested the vapor-liquid-solid growth mechanism (vls). scanning elect...

The authors present a manufacturing cost analysis for producing thin-film indium phosphide modules by combining a novel thin-film vapor–liquid–solid (TF-VLS) growth process with a standard monolithic module platform. The example cell structure is ITO/n-TiO2/p-InP/Mo. For a benchmark scenario of 12% efficient modules, the module cost is estimated to be $0.66/W(DC) and the module cost is calculat...

This paper proposes a novel cache architecture suitable for merged DRAM/logic LSIs, which is called “dynamically variable line-size cache (D-VLS cache).” The D-VLS cache can optimize its line-size according to the characteristic of programs, and attempts to improve the performance by exploiting the high on-chip memory bandwidth on merged DRAM/logic LSIs appropriately. In our evaluation, it is o...