QUESTION 1 What sequences should be obtained on magnetic resonance imaging (MRI) to evaluate vestibular schwannomas before and after surgery? TARGET POPULATION Adults with vestibular schwannomas. RECOMMENDATIONS Initial Preoperative Evaluation Level 3: Imaging used to detect vestibular schwannomas should use high-resolution T2-weighted and contrast-enhanced T1-weighted MRI. Level 3: Standar...

INTRODUCTION We present a series of head and neck extracranial non-vestibular schwannomas treated during a ten-year period, assessing epidemiology, presenting signs and symptoms, location, nerve of origin, diagnostic modalities, treatment and clinical outcome. MATERIALS AND METHODS Clinical records of all patients with head and neck schwannomas treated at our department from April 1995 to Jul...

Spinal schwannomas are frequently observed among patients treated in a reference neurosurgery center. Cystic spinal schwannomas, however, are very scantly found. Due to its indolent behavior and benign course, the diagnosis of schwannomas may pose a challenge to the care giver, and the imaging findings can be misleading. In this article, we illustrate an example of a pauci-symptomatic 55 year-o...

miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system. These benign tumors typically result from loss of the neurofibromatosis type 2 (NF2) tumor suppressor gene. We have recently carried out high-throughput miR...

BACKGROUND Retroperitoneal schwannomas are very rare and are usually found incidentally. CASES REPORT Two rare cases of retroperitoneal schwannomas are reported. Both were incidentally found during US scans for non-specific epigastric pain and were initially diagnosed as non-secreting retroperitoneal tumors. The diagnosis was confirmed by CT scan. In both patients the tumors were resected. Th...

Bovine peripheral nerve sheath tumours from 30 cattle were similar ultrastructurally to human schwannomas and neurofibromas. Bovine neurofibromatous tissue had large amounts of extracellular material, primarily collagen and electron lucent granular material. The principal cells had basal laminae and a disorganized proliferation of the plasmalemma. Axons were consistently seen and were surrounde...

Vestibular schwannomas are the most common cerebellopontine angle tumor. During the past century, the management goals of vestibular schwannomas have shifted from total resection to functional preservation. Current treatment options include surgical resection, stereotactic radiosurgery, and observation. Imaging has become a crucial part of the initial screening, evaluation, and follow-up assess...

Schwannomas are encapsulated, benign tumors, which generally originate from the schwann cells on cranial or peripheral nerves. Malignant transformation into neurofibrosarcoma occurs in 1% of these tumors. While schwannomas account for 8% of all central nervous system tumors, intracerebral schwannomas occurring independent from cranial nerves are extremely rare. Their treatment is usually surgic...

Schwannomas, or neurilemmomas (as they are occasionally called), typically present as firm, encapsulated masses with a solid to partly cystic gross appearance. These benign neoplasms originate from Schwann cells, which develop during the fourth week of gestation during the ectomesenchymal detachment of the neural crest. They subsequently form an envelope around extracranial nerve fibers, provid...