Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first specific chromosomal abnormality associated with cancer to the development of imatinib as a specific, targeted therapy for the disease. The successful development of imatinib as a therapeutic agent for CML can be attributed directly to decad...

Using the accumulative publication data on HER-2 and its trend line, we draw the accumulative curve of the publication data. We discuss the characteristics of the accumulative publication curve, and how these characteristics change with respect to the different trend lines. We find that the points that regression line and the publication curve intersect with each other and the minimum points wi...

background: empirical inculcation is vital for producing quality research professionals and upon realizing the increasing demand of emerging scientific research professionals, national academy of young scientist (nays) launched its science for youth (s4y) program in pakistan with its emphasis on empiricism. methods: s4y team was galvanized to undertake this task and different scientific activit...

Editor-in-Chief Dan Nocera encourages the chemical science community to share the wealth of their most exceptional scientific discoveries, so that this is freely available to all.

Evolutionary psychology provides a cogent metatheory for psychological science. It has furnished compelling theories of major domains of human functioning, including mating, parenting, kinship, morality, cooperation, conflict, aggression, and aesthetics. It has produced hundreds of empirical discoveries missed entirely by prior psychologists. Developmental dynamics, properly conceived, can add ...

Traditional science searched for new objects and phenomena that led to discoveries. Tomorrow's science will combine together the large pool of information in scientific archives and make discoveries. Scientists are currently keen to federate together the existing scientific databases. The major challenge in building a federation of these autonomous and heterogeneous databases is system integrat...

S propensity for making surprising discoveries—is common throughout biology. Prominent examples include the discoveries of penicillin (Fleming 1929), meiosis (Beneden 1883), and cellular immunity (Metchnikoff 1901). It has been argued that major scientific discoveries cannot be premeditated, that they are instead the consequence of scientific preparedness of mind and, to a lesser degree, luck (...

There has been an increasing concern that most published medical findings are false. But what does it mean to be false? Here we describe the range of definitions of false discoveries in the scientific literature. We summarize the philosophical, statistical, and experimental evidence for each type of false discovery. We discuss common underpinning problems with the scientific and data analytic p...

Scientific journals serve as two-sided knowledge platforms that facilitate the diffusion of scientific knowledge. Journals offer an outlet for scientists to disclose their findings in a way that allow others to evaluate the importance of their discoveries (e.g., through the reviewing process and the reputation of a journal) and, at the same time, are a principal means by which follow-on researc...

http://ajp.psychiatryonline.org On the “Infallibility” of Psychopathology and Its Implications for Action Initial enthusiasm about discoveries in our field has evolved into questions about the meaning and future of current scientific approaches. The first set of questions has to do with the validity of information derived from biological and psychosocial sciences in understanding psychopatholog...