PURPOSE Scleral remodeling is an important mechanism underlying the development of myopia. Atropine, an antagonist of G protein-coupled muscarinic receptors, is currently used as an off-label treatment for myopia. Regulator of G-protein signaling 2 (RGS2) functions as an intracellular selective inhibitor of muscarinic receptors. In this study we measured scleral RGS2 expression and scleral remo...

RATIONALE We report 3 cases of a torn haptic after successful scleral fixation with a hydrophobic acrylic intraocular lens. PATIENT CONCERNS Patients complained of decreased visual acuity about 1 week to 1 month after scleral fixation. DIAGNOSES In all 3 cases, the direction of the damaged haptic correlated with the direction of the pulling force made by the hung suture material. Observatio...

INTRODUCTION Mooren's ulcer is a rare disorder of unknown etiology that is refractory to treatment. It can affect not just the cornea but also the scleral tissue and can involve both eyes. CASE PRESENTATION We report a case of a 74-year-old man with a history of bilateral and malignant Mooren's ulcer. The patient had undergone an exenteratio bulbi of the left eye because of the perforation of...

A case of senile scleral plaques is reported in which expulsion of a calcified plaque anterior to the insertion of the medial horizontal rectus muscle gave rise to senile scleromalacia. Histopathological examination revealed a second calcified plaque at the site of the contralateral senile scleral plaque in this eye. This case indicates that senile scleromalacia is a scleral disease sui generis...

CASE REPORT Intrusion is defined as erosion and protrusion of the scleral implant into the vitreous cavity. This condition may occur as a retinal detachment, vitreous hemorrhage, endophthalmitis or be without symptoms. We performed a vitrectomy alone in a patient with relapsing vitreous hemorrhage secondary to the intrusion of a scleral buckle implanted 19 years previously and left intact the i...

Purpose. To evaluate the efficacy of autologous tenon grafting combined with conjunctival flap as a treatment for scleromalacia or scleral thinning after pterygium excision without any additional donor graft tissue. Methods. Twenty-six cases underwent autologous advanced tenon grafting combined with sliding or rotating conjunctival flap for scleromalacia after pterygium surgery ranging from 2 y...

PURPOSE To determine the in vitro permeability of the sclera to high molecular weight compounds and the relationship between scleral permeability and molecular size. METHODS Fresh rabbit sclera was mounted in a two-chamber diffusion apparatus, and its permeability to sodium fluorescein, fluorescein isothiocyanate (FITC)-conjugated bovine serum albumin, FITC-IgG, and FITC dextrans ranging in m...

The scleral spur and scleral roll together form a fibrous hoop which may be detached from adjacent structures as a unit. Tensile tests of the spur-roll resemble reported data on sclera. It is proposed that the circular structure of the spur-roll prevents action of the meridional portion of the ciliary muscle on the trabecular meshwork from collapsing the canal of Schlemm.

Posterior scleral tuberculoma formation is an extremely rare condition. The few reports on scleral involvement in tuberculosis refer to cases of anterior scleritis. In the present manuscript we describe a patient who had rheumatoid arthritis and developed a large posterior scleral tuberculoma. The lesion provoked retinal detachment and visual loss and was diagnosed only after enucleation due to...