a In recent years, graphene and transition metal dichalcogenides (TMDs) have been at the forefront of candidate materials for next-generation electronic devices. In this study, we will consider transition metal oxides (TMOs), which are a class of materials that can exist in two-dimensional geometries, but exhibit unique properties due to the strong correlation between electrons. Density functio...

Resistance breathing improves tolerance to central hypovolemia induced by lower body negative pressure (LBNP), but this is not related to protection of anterior cerebral blood flow [indexed by mean middle cerebral artery velocity (MCAv)]. We hypothesized that inspiratory resistance breathing improves tolerance to central hypovolemia by maintaining cerebral oxygenation (ScO2), and protecting cer...

Nielsen, H. B., R. Boushel, P. Madsen, and N. H. Secher. Cerebral desaturation during exercise reversed by O2 supplementation. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1045–H1052, 1999.—The combined effects of hyperventilation and arterial desaturation on cerebral oxygenation (ScO2) were determined using near-infrared spectroscopy. Eleven competitive oarsmen were evaluated during a 6-min...

Sco1 and Sco2 are mitochondrial copper-binding proteins involved in the biogenesis of the Cu(A) site in the cytochrome c oxidase (CcO) subunit Cox2 and in the maintenance of cellular copper homeostasis. Human Surf1 is a CcO assembly factor with an important but poorly characterized role in CcO biogenesis. Here, we analyzed the impact on CcO assembly and tissue copper levels of a G132S mutation ...

Wrought and additively manufactured (AM) 316 L stainless steel samples were exposed to a simulated Brayton cycle supercritical CO2 (sCO2) environment, at temperature of 450 °C pressure 76 bar in 99.999% for 2 weeks. The ground surfaces wrought AM specimens had average oxide thickness 95 51 µm, respectively, composed primarily Fe Cr oxides. An as-printed sample was also the sCO2 environment exhi...

Studies on harnessing solidified carbon dioxide (SCO2) for municipal sewage sludge (MSS) pre-treatment have been conducted exclusively in batch reactors. This makes it difficult to accurately assess how long-term SCO2 treatment affects anaerobic digestion (AD) conditions and performance. The aim of our study was evaluate the effect MSS with AD conditions, bacterial community, biogas composition...

Mitochondria are organelles responsible for vital cell functions. p53 is a transcription factor that regulates the DNA stability and cell growth normality. Recent studies revealed that p53 can influence mitochondrial function changing from normal condition to abnormal condition under different stress levels. In normal state, p53 can maintain mitochondrial respiration through transactivation of ...

The purpose of this study was to outline the timelines of mitochondrial function, oxidative stress and cytochrome c oxidase complex (COX) biogenesis in cardiac muscle with age, and to evaluate whether and how these age-related changes were attenuated by exercise. ICR/CD-1 mice were treated with pifithrin-μ (PFTμ), sacrificed and studied at different ages; ICR/CD-1 mice at younger or older ages ...

Cardiomyocyte hypertrophy induced by phenylephrine (PE) is accompanied by suppression of cytochrome c oxidase (CCO) activity, and copper (Cu) supplementation restores CCO activity and reverses the hypertrophy. The present study was aimed to understand the mechanism of PE-induced decrease in CCO activity. Primary cultures of neonatal rat cardiomyocytes were treated with PE at a final concentrati...