The effect of premedication with morphine and scopolamine, morphine alone, and scopolamine alone on arterial oxygen tension has been studied in patients with coronary artery disease undergoing bypass operations. Control arterial blood samples were obtained with the patients in the supine position breathing room air the day before operation. A second arterial blood sample was taken in the induct...

The muscarinic receptor antagonist scopolamine was microinjected into either the preoptic area or the lateral ventricle, preceding sexual behavior tests. In Experiment 1 unilateral ventricular injections of scopolamine delayed the initiation of copulation, while unilateral preoptic injections had no effect. In Experiment 2 bilateral injections into the preoptic area produced dose-related decrea...

Owing to progressive aging in the population, there is an increase patients with cognitive impairment. For prevention of dementia, use plant remedies relevant. Of particular interest Klasea centauroides (L.) Cass. (Serratula L., Asteraceae), which has significant natural reserves, contains a wide range biologically active substances, and used folk medicine treat nervous system diseases. This st...

alzheimer is a progressive neurodegenerative disorder in which oxidative stress plays a major role. the present study was designed to investigate neuroprotective effect of lornoxicam, selegiline and co-administration of both drugs in scopolamine induced cognitive impairment and neurodegeneration. scopolamine (1.4mg/kg) was administered intraperitoniallyin male wistar rats. rectangular maze perf...

Transdermal scopolamine has been widely used for the prevention of motion-sickness by travelers due to its potent anticholinergic effects and the ease of administration. Nevertheless, its effects on sleep physiology are not known, despite the wellknown fact that the administration of scopolamine as an injection or an oral form could influence the sleep architecture, especially prolonging rapid ...

OBJECTIVES We hypothesized that by enhancing parasympathetic activity, low dose transdermal scopolamine would increase heart rate variability after myocardial infarction. BACKGROUND Low heart rate variability is associated with increased mortality after acute myocardial infarction. METHODS Conventional time domain heart rate variability was measured from 24-h Holter recordings of 61 consecu...

Circadian variation in susceptibility to the ambulation-increasing effect of scopolamine in mice was investigated. The mice housed under a 12-hr light-dark situation (light period: 6:00-18:00 and dark period: 18:00-6:00) for 5 weeks were administered scopolamine HBr at 0.5 or 2 mg/kg s.c. at one of six times of the day (3:00, 7:00, 11:00, 15:00, 19:00 and 23:00), and the ambulatory activity was...

Hyoscyamine-6beta-hydroxylase (H6H; EC 1.14.11.11) catalyses oxidative reactions in the biosynthetic pathway leading from hyoscyamine to the more pharmaceutically valuable tropane alkaloid scopolamine. The h6h gene encoding H6H from Hyoscyamus niger was introduced, under the control of the CaMV 35S promoter, into non-hyoscyamine-producing Nicotiana tabacum and hyoscyamine-producing Hyoscyamus m...

Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. The present study aimed to investigate the effects of vitexin (5, 7, 4-trihydroxyflavone-8-glucoside), a flavonoid found in such plants as tartary buckwheat sprouts, wheat leaves phenolome, Mimosa pudica Linn and Passiflora spp, on scopolamine-induced memory impairment in rats. To achieve this goal, we...

The cholinergic system has long been implicated in learning and memory, yet its specific function remains unclear. In the present study, we investigated the role of cortical acetylcholine in a rodent model of declarative memory by infusing the cholinergic muscarinic receptor antagonist scopolamine into the rat perirhinal cortex during different stages (encoding, storage/consolidation, and retri...