We describe 6 patients with scrub typhus who presented with acute hearing loss, a forgotten complication of this reemerging disease. They were admitted with fever of 10-14 days' duration and had clinical evidence of deafness and pneumonitis. Five patients had eschars, which prompted the diagnosis of typhus fever and led to early institution of treatment. Deafness has been described as a clue to...

Introduction Scrub typhus is a potentially fatal infectious disease caused by the organism Orientia tsutsugamushi. It may clinically present as acute flu like syndrome, hepatic dysfunction, pulmonary involvement, cardiovascular, renal dysfunction, aseptic meningitis and multiorgan involvement. A high degree of clinical suspicion and knowledge of the various radiologic manifestations of scrub ty...

BACKGROUND Scrub typhus is a mite-borne bacterial infection of humans caused by Orientia tsutsugamushi that causes a generalized vasculitis that may involve the tissues of any organ system. The aim of this study was to identify factors associated to severe complications from scrub typhus. METHODS We conducted this prospective, case-control study on scrub typhus patients who presented to the D...

Background: Scrub typhus is a mite-borne bacterial infection caused by Orientia tsutsugamushi. Hemophagocytic lymphohistiocytosis (HLH) is a potential severe complication. Most reported cases of HLH associated with scrub typhus were single cases or case series with a small sample sizes. Thus, no clear consensus exists on clinical manifestations and differences between pediatric and adult cases ...

Scrub typhus is an acute, and sometimes fatal, human febrile illness, typically successfully treated using chloramphenicol or one of the tetracyclines. Over the past several years, descriptions of strains of Orientia tsutsugamushi with reduced susceptibility to antibiotics have appeared. Because case-fatality ratios approached 50% during the pre-antibiotic era, antibiotic-resistant scrub typhus...

Background: Scrub typhus is caused by Orentia (formerly Rickettsia) tsutsugamushi. It is an infectious disease of variable severity .Scrub typhus has a wide geographical distribution. Scrub typhus is grossly under diagnosed in India due to its nonspecific clinical presentation, limited awareness and low index of suspicion. Methods: This study was a cross sectional observational study conducted ...

BACKGROUND The aim of this study is to identify the factors associated with the occurrence of pleural effusion and to investigate the characteristics of pleural effusion in scrub typhus. METHODS We conducted a retrospective analysis of the medical records of scrub typhus patients between January 2004 and December 2011 at Chosun University Hospital in South Korea. A total of 445 scrub typhus p...

BACKGROUND Natural killer (NK) cells are essential immune cells against several pathogens. Not much is known regarding the roll of NK cells in Orientia tsutsugamushi infection. Thus, this study aims to determine the level, function, and clinical relevance of NK cells in patients with scrub typhus. METHODOLOGY/PRINCIPAL FINDINGS This study enrolled fifty-six scrub typhus patients and 56 health...

1. Yu ES, Lin JR. Studies on the treatment of scrub typhus by antibiotics and problems produced by immune development. Acta Microbiol Sin. 1958;6:69–73. 2. Yu ES. Studies on the ecology of trigger mite and its prevention strategies. ACTA Entomologica Sinica. 1957;7:363–72. 3. Guo HB, Yu MM, Xu MH, Tang JQ, Wu GH. Studies on serological typing of antiRickettsia tsutsugamushi antibody in Jiangsu....

Diagnosis of scrub typhus is challenging due to its more than twenty serotypes and the similar clinical symptoms with other acute febrile illnesses including leptospirosis, murine typhus and hemorrhagic fever with renal syndrome. Accuracy and rapidity of a diagnostic test to Orientia tsutsugamushi is an important step to diagnose this disease. To discriminate scrub typhus from other diseases, t...