PURPOSE To elucidate the relation between infiltrating cytotoxic T lymphocytes and the expression of MUC1 and sialoglycans in malignant eyelid tumors. METHODS The distribution of MUC1, Maackia amurensis lectin-II (MAL-II)-recognized sialoglycan, and CD8-positive T lymphocytes was examined histochemically in 14 patients with malignant eyelid tumors: three squamous cell carcinomas, six sebaceou...

Sebaceous carcinoma is a rare locally aggressive neoplasm of the sebaceous gland, which occurs frequently in elderly males. It constitutes 0.2 to 4.6% all malignant cutaneous tumours and commonly periocular area. Scalp site for this tumor. Here we report case young 28 years old male patient who presented with firm hard exophytic growth over right posterior occipital region enlarged suboccipital...

Nevus sebaceous is a hamartoma of the cutaneous structures that often presents at birth and typically involves the face and scalp. Nevus sebaceous is frequently complicated by the development of a variety of other benign or malignant neoplasms. The most frequently reported benign neoplasms are trichoblastoma and syringocystadenoma papilliferum. Malignant tumors are much less frequently observed...

OBJECTIVE To provide clinical details and long-term outcome data for a series of patients with eyelid or conjunctival melanoma or eyelid sebaceous cell carcinoma who underwent sentinel lymph node (SLN) biopsy. DESIGN Retrospective interventional case series with review of clinical records and pathologic specimens. SETTING Tertiary comprehensive cancer center. PATIENTS Twenty-five consecut...

We report a patient who developed sebaceous carcinoma on the neck during therapy with immunosuppressive agents (cyclosporine, corticosteroid, methotrexate) for refractory psoriasis vulgaris, which showed rapid enlargement, leading to a fatal outcome. Multiple-organ metastases were detected. Weekly carboplatin + paclitaxel therapy resulted in the disappearance of tumor cells, but the patient die...

Sebaceous cell carcinoma continues to defy clinicians and pathologists in terms of early diagnosis. The tumor may be mistaken as benign lesions such as chalazion and blepharitis, and also as malignant neoplasms, mainly basal cell carcinoma and squamous cell carcinoma. Despite advances in immunohistochemical analysis and treatment options during the last decades, morbidity and metastasis rates r...

Background:
 Sebaceous carcinoma is a rare and potentially aggressive cutaneous malignancy. It derived from the adnexal epithelium of sebaceous glands tends to hold diverse clinical presentation. Although it often reported in periocular region, can manifest any unit skin. Due rarity this condition, prognostic demographic factors are largely indeterminate. Hence, we sought assess impact soc...

INTRODUCTION Sebaceous gland tumours are rare and their presence should be considered as a marker for Muir-Torre Syndrome, alerting to search for an occult malignancy. CASE PRESENTATION A 43-year-old Caucasian female patient underwent excision of a sebaceous cyst. Histopathology confirmed a sebaceous carcinoma. Further investigations revealed multiple intra-abdominal malignancies. She has bee...

INTRODUCTION Breast cancer is common in women and its metastases involve the skin in approximately one quarter of patients. Accordingly, metastatic breast cancer shown to be cutaneous through histology must be distinguished from a wide variety of other neoplasms as well as the diverse morphologic variants of breast cancer itself. CASE PRESENTATION We report the case of a 61-year-old Caucasian...

BACKGROUND Sebaceous carcinoma of the breast is a distinct variant of invasive ductal carcinoma. It is rare and only several cases have been reported. CASE PRESENTATION An 80-year-old woman noted bloody discharge from her left nipple and palpated a lump in her left breast. Ultrasonography revealed a 19-mm mass in the left breast. Fine-needle aspiration suggested invasive ductal carcinoma. Par...