نتایج جستجو برای: secreted frizzled related protein

تعداد نتایج: 2291761  

Journal: :Biochimica et biophysica acta 2014
Rohit Surana Sakshi Sikka Wanpei Cai Eun Myoung Shin Sudha R Warrier Hong Jie Gabriel Tan Frank Arfuso Simon A Fox Arun M Dharmarajan Alan Prem Kumar

The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
Maria Mirotsou Zhongyan Zhang Arjun Deb Lunan Zhang Massimiliano Gnecchi Nicolas Noiseux Hui Mu Alok Pachori Victor Dzau

Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and ...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2013

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