In vivo radiopharmaceuticals have two different uses - for nuclear diagnostic imaging and for internal radiation therapy. For nuclear diagnostic imaging, it is necessary to make the difference of radioactivity levels between in the target regions and in the other regions at an early time after administration. For internal radiation therapy, a more selective accumulation of the radioactivity to ...

© I a l Today drugs are almost exclusively manufactured industrially. This has been driven by cost savings, but also by a public mandate of high quality and especially standardization, that is difficult to maintain in a non-industrial setting. On the other hand the same public asks for “personalized”or “precision medicine”(Reza Mirnezami et al. 2012) precisely tailored to each patient’s require...

Radiopharmaceuticals are radioactively labeled compounds fulfilling the requirements of pharmaceutical products, used in radio diagnosis or radiotherapy. One essential parameter in the quality control of radiopharmaceuticals is the radionuclidic purity. In this work, we present aspects regarding the radionuclidic purity determination for the radiopharmaceutical products: Sodium Iodide (I) solut...

gallium-68 a positron emitter radionuclide, with great impact on the nuclear medicine, has been widely used in positron emission tomography (pet) diagnosis of various malignancies in humans during more recent years especially in neuroendocrine tumors (nets). the vast number of 68ge/68ga related generator productions, targeting molecule design (proteins, antibody fragments, affibodies, peptides ...

Because radiopharmaceuticals are intended for human administration, quality control procedures are essential in ensuring the safety of these preparations. Although extensive quality control procedures are performed by the manufacturer, many radiopharmaceutical preparations are prepared in nuclear medicine departments using kits and short-lived radionuclides including technetium-99m CmTc) and in...

BACKGROUND Dopamine D2/3 receptor (D2/3R) agonist radiopharmaceuticals are considered superior to antagonists to detect dopamine release, e.g. induced by amphetamines. Agonists bind preferentially to the high-affinity state of the dopamine D2R, which has been proposed as the reason why agonists are more sensitive to detect dopamine release than antagonist radiopharmaceuticals, but this theory h...

The influence of effective room temperature on the radiochemical purity of 99mTc-radiopharmaceuticals was reported. This study was born from the observation that in the isolators used for the preparation of the 99mTc-radiopharmaceuticals the temperatures can be higher than those reported in the commercial illustrative leaflets of the kits. This is due, in particular, to the small size of the wo...

Purified field bean protease inhibitor (FBPI) was labeled with 99mTcO4- to ascertain its ability to locate tumors in tumor-bearing rat models. The labeling was done with Sn2+ as a reducing agent and the yield was 95%. It was stable for 2 hr at ambient temperature. The biodistribution study of the intravenously injected radiolabeled FBPI in normal Wistar rats at various time intervals showed a r...

PET (positron emission tomography) is a powerful imaging technique that can provide quantitative information on the distribution of positron emitter labeled radiopharmaceuticals (PET radiopharmaceuticals) in the body. Positrons (ß+) are positively charged beta particles. They are emitted when the atom is proton rich. A positron has only a transient existence. After losing all of its kinetic ene...