In previous studies stationary phase optimized selectivity liquid chromatography (SOSLC) has been already proved as a promising technique to optimize the selectivity of a given separation [1, 2]. By combination of different stationary phases, SOSLC offers excellent possibilities for method development under both isocratic and linear gradient conditions. However, the so far available commercial ...

BACKGROUND In primary focal and segmental glomerulosclerosis (FSGS) renal prognosis is poor if no remission of proteinuria can be obtained by treatment. In some patients a permeability factor, responsible for damaging the glomerular epithelial cell and detectable by an in vitro test (GVV-test), seems to be present in the serum. METHOD We determined the effects of an immunadsorption treatment ...

abstract background: molecular imprinting is a method for synthesizing polymers with structure-selective adsorption properties with applications such as, selectivity binding, drug delivery systems and anti-bodies. the present study aims at optimizing the preparation of molecularly imprinted polymer (mip) against l-phenylalanine, in order to increase phenylalanine-binding in enzymatic intestinal...

The resorcylic acid lactone hypothemycin has been shown to inactivate protein kinases by binding to a cysteine conserved in 46 protein kinases, including mitogen-activated protein kinase kinase (MEK), extracellular signal-regulated kinase (ERK) and platelet-derived growth factor receptor (PDGFR). We assessed the selectivity of hypothemycin in cellular contexts. Hypothemycin normalized the morph...

A novel continuous flow process for selective hydrogenation of α, β-unsaturated aldehyde (cinnamaldehyde, CAL) to the unsaturated alcohol (cinnamyl alcohol, COL) has been reported in a tube reactor coated with a Pt/SiO2 catalyst. A 90% selectivity towards the unsaturated alcohol was obtained at the aldehyde conversion of 98.8%. This is a six-fold improvement in the selectivity compared to a bat...

Dry-column vacuum chromatographic technique is introduced for remediation of wastewater the first time. A previously prepared chemically modified silica gel containing covalently immobilized Hg2+-selective acridino-crown ether selector molecules was used as an adsorbent. Removal Hg2+ from highly contaminated river water carried out to study practical applicability. Adsorption capacity, preconce...

A new ZORBAX stationary phase, Agilent ZORBAX Eclipse Plus Phenyl-Hexyl, separated five estrogen type steroids better than a C18 and better than three other phenyl columns under identical conditions, due to its unique selectivity for analytes containing phenyl groups. The comparisons support selectivity as the most important factor to optimize resolution, to separate peaks completely. Selectivi...

Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain, commonly L858R or deletions within exon 19, increase EGFR-driven cell proliferation and survival and are correlated with impressive responses to the EGFR inhibitors erlotinib and gefitinib in nonsmall cell lung cancer patients. Approximately 60% of acquired resistance to these agents is driven by a single sec...