Primary motoneurons, the earliest developing spinal motoneurons in zebrafish, have highly stereotyped axon projections. Although much is known about the development of these neurons, the molecular cues guiding their axons have not been identified. In a screen designed to reveal mutations affecting motor axons, we isolated two mutations in the stumpy gene that dramatically affect pathfinding by ...

Some patients with schizophrenia present a related phenomenon in which they believe their limbs are under the control of an alien force (motor passivity).5 There are some attempts to elucidate the nature and mechanism of passivity phenomena (experiences that one’s conscious actions or thoughts have not been ‘willed’ by oneself) wich include the dysfunction of an internal self-monitoring system ...

OBJECTIVES The purpose of this study was to examine the effectiveness of a 30-week fundamental motor skill program in typically developing young children and to investigate possible sex differences. DESIGN A multicenter quasi experimental design was set up for this study which involved 992 children aged 3-8 years. METHODS All participants received their typical Physical Education curriculum...

Layer 5 neurons of the neocortex receive direct and relatively strong input from the thalamus. However, the intralaminar distribution of these inputs and their capacity for plasticity in adult animals are largely unknown. In slices of the primary motor cortex (M1), we simultaneously recorded from pairs of corticospinal neurons associated with control of distinct motor outputs: distal forelimb v...

PURPOSE Although visual analysis, motor coordination, and visual-motor integration can each affect performance on a test of visual motor integration, previous studies have not reported the relative importance of these components to the relation between visual motor integration and learning readiness, reading, and math. This investigation relates academic achievement in reading and math to perfo...

BACKGROUND To investigate the epidemiology of a steep decrease in the incidence of suicide deaths in Australia. METHODS National data on suicide deaths and deliberate self-harm for the period 1994-2007 were obtained from the Australian Institute of Health and Welfare. We calculated attempt and death rates for five major methods and the lethality of these methods. Negative binomial regression ...

Inhibiting impulsive reactions while still defending one's vital resources is paramount to functional self-control and successful development in a social environment. However, this ability of successfully inhibiting, and thus controlling one's impulsivity, often fails, leading to consequences ranging from motor impulsivity to aggressive reactions following provocation. Although inhibitory failu...