Under acute perturbations from outer environment, a normal cell can trigger cellular self-defense mechanism in response to genome stress. To investigate the kinetics of cellular self-repair process at single cell level further, a model of DNA damage generating and repair is proposed under acute Ion Radiation (IR) by using mathematical framework of kinetic theory of active particles (KTAP). Firs...

While neuromorphic computing architectures based on Spiking Neural Networks (SNNs) are increasingly gaining interest as a pathway toward bio-plausible machine learning, attention is still focused computational units like the neuron and synapse. Shifting from this neuro-synaptic perspective, paper attempts to explore self-repair role of glial cells, in particular, astrocytes. The work investigat...

The emerging field of self-repair computing could have a major impact on deployable systems for space missions and defense applications. These systems must survive and perform at optimal functionality for long durations in unknown, harsh, and/or changing environments. Examples of such applications include outer solar system exploration, missions to comets and planets with severe environmental c...

In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability (PR) synapses; the enhancement of the transmission PR of a healthy neighboring synapse by retrograde signaling can enhance the transmission PR of the "faulty" synapse (repair). Our model of...

Developmental biology requires three principles of organization characteristic of living organisms: multicellular architecture, cellular division, and cellular differentiation. Implemented in silicon according to these principles, new computing machines become able to grow, to self-replicate, and to self-repair. The introduction of a new algorithm for cellular division, the so-called Tom Thumb ...

In this paper, we present the description and evaluation of a novel physical design tool, BISRAMGEN, that can generate reconfigurable and fault-tolerant RAM modules. This tool, first proposed in [3], designs a redundant RAM array with accompanying built-in self-test (BIST) and built-in self-repair (BISR) logic that can switch out faulty rows and switch in spare rows. Built-in self-repair causes...