Objective(s): One of the main constraints of collagen hydrogel scaffolds for using in tissue engineering is mechanical weakness. Plastic compression (PC) is a physical method to overcome the mechanical limitation of collagen hydrogel. Materials and Methods: In this study, the effects of pH on mechanical and biological properties of PC hydrogels were investigated. Collagen hydrogels were fabrica...

Micropatterning techniques that control three-dimensional (3D) arrangement of biomolecules and cells at the microscale will allow development of clinically relevant tissues composed of multiple cell types in complex architecture. Although there have been significant developments to regulate spatial and temporal distribution of biomolecules in various materials, most micropatterning techniques a...

The present work focused on the design of drug delivery system (DDS) based on a pH-,saltand temperature sensitive superabsorbent hydrogel.The novel biopolymer-based superabsorbent hydrogels were prepared by grafting crosslinked poly(AA-co-BuMC) chains onto CMC backbones through a free radical polymerization method. the hydrogel,s structure was confirmed using FTIR spectroscopy. Results from sca...

Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH-sensitive poly(N-vinyl 2-pyrrolidone/itaconic acid) P(VP/IA) hydrogels were investigated. P(VP/IA) hydrogels were prepared by irradiating the ternary monomer mixtures of N-vinyl 2-pyrrolidone/itaconic acid/ethylene glycol dimethacrylate in aqueous solution by -rays at ambient temperature. Hydrogels containin...

A core-clad fiber made of elastic, tough hydrogels is highly stretchable while guiding light. Fluorescent dyes are easily doped into the hydrogel fiber by diffusion. When stretched, the transmission spectrum of the fiber is altered, enabling the strain to be measured and also its location.

Dual thermoand pH-responsive comb-type grafted hydrogels of poly(N,N-dimethy laminoethyl methacrylate) (PDMAEMA) and poly(N-isopropylacrylamide) (PNIPAM) with reversed network-graft architectures were synthesized by the combination of atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT) polymerization and click chemistry. Two kinds of macro-cross-...

Hydrogels are introduced to modem medicine as novel materials suitable for a variety ofbiomedical applications. Studying hydrogels as novel biomaterials has become a fast-developingand exciting research field during the last two decades. These interesting biomaterials have found awide range of application including contact lenses, vehicles for drug delivery and scaffold in tissueengineering and...