Brief, localized, cutaneous, non-painful thermal stimuli can evoke a transient vasomotor response, causing increased cutaneous blood flow and elevated skin temperature. The aims of this study were to investigate 1) if cutaneous sensitization by topical application of capsaicin (TRPV1 receptor agonist) can facilitate the size, duration and spatial extent of this vasomotor response and 2) if male...

Rebekah Stevenson: Characterization of Adolescent and Adult Ethanol Sensitization (Under the direction of Dr. Clyde Hodge) Alcoholism is a serious health problem that affects the lives of millions of people worldwide. People that first experiment with alcohol as adolescents are at a greater risk to become alcoholics. The adolescent brain may be particularly vulnerable to druginduced neuroadapta...

background: atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about common food allergens in iranian children with atopic dermatitis. objectives: this study was des...

Even though nociceptive pathology has often long subsided, the brain of patients with chronic musculoskeletal pain has typically acquired a protective (movement-related) pain memory. Exercise therapy for patients with chronic musculoskeletal pain is often hampered by such pain memories. Here the authors explain how musculoskeletal therapists can alter pain memories in patients with chronic musc...

Background Lipid Transfer Proteins (LTP) and profilins are the most important panallergens in the clinical management of patients with allergy to pollen and plant food (mainly tree nuts and fresh fruits) in the Mediterranean countries. Knowledge of the prevalence of sensitization to these allergens in the population would be extremely useful. In this study we analyze the frequency of sensitizat...

Tumor necrosis factor (TNF) signaling is required for inflammatory nociceptive (pain) sensitization in Drosophila and vertebrates. Nociceptive sensitization in Drosophila larvae following UV-induced tissue damage is accompanied by epidermal apoptosis and requires epidermal-derived TNF/Eiger and the initiator caspase, Dronc. Major gaps remain regarding TNF function in sensitization, including th...

RATIONALE Recent observations, especially in adults, suggest that asthma severity may be associated with fungal sensitization. Other studies suggest that some patients with severe asthma and fungal sensitization may benefit from anti-fungal therapy. Currently, the prevalence of fungal sensitization among children with severe asthma is not well characterized. METHODS We determined prevalence o...

INTRODUCTION Peripheral and central sensitization are neurophysiological processes that can prolong painful conditions. Painful shoulder conditions are often persistent, perhaps due to the presence of sensitization. METHOD This manuscript summarizes six studies that have evaluated those with musculoskeletal shoulder pain for the presence of sensitization. RESULTS All six manuscripts report ...

Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization). Our aim was to compare basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone and enhanced calcium entry-spontaneou...

Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. The present study reexamined the effects of the daily injection of phencyclidine on locomotor activity and stereotypy in rats, and investigated whether drug-environment conditioning was necessary for the development of behavioral s...