OBJECTIVE To determine immunogenicity and safety of intradermal (ID) influenza vaccines compared with intramuscular (IM) administration and effect of dose and age. DESIGN Meta-anlysis. SETTING Systematic review and meta-analysis of randomized controlled trials on influenza vaccines. SAMPLE Randomized, controlled trials comparing ID seasonal split-virus influenza vaccines with 15 μg IM con...

Objective To determine seroprotection and vaccine response rates produced by a diphtheria–tetanus–acellular pertussis–inactivated poliovirus–Haemophilus influenzae type-b conjugate (DTaP–IPV//PRP~T) vaccine containing a polyribosyl-ribitol-phosphate (PRP)– tetanus toxoid conjugate (PentaximTM) and given with a hepatitis B vaccine. Methods In this multicentre open-label trial, 424 infants who re...

OBJECTIVE To assess the potential acute effects regarding the immunogenicity and safety of non-adjuvanted influenza A H1N1/2009 vaccine in patients with mixed connective tissue disease and healthy controls. METHODS Sixty-nine mixed connective tissue disease patients that were confirmed by Kasukawa's classification criteria and 69 age- and gender-matched controls participated in the study; the...

Background: Due to their similar routes of transmission, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infection occurs considerably. HBV infection progresses more rapidly in HIV-infected patients. Therefore, HBV vaccination of all non-immune HIV infected patients is recommended. On the other hand, HIV-infected subjects have suboptimal responses to HBV vaccine. In this study...

objective: preventing communicable diseases in the armed forces (af) of a country is considered as a national interest and has a great importance. there are limited data on the efficacy of vaccination of the navy personnel. this study was designed to evaluate both the safety and the immunogenicity of a recombinant hepatitis b (hb) vaccine made by pasteur institute of iran (ipi-rhb), in this tar...

To determine if newer influenza vaccines can safely improve seroprotection rates of older adults, we compared three licensed trivalent inactivated vaccines (TIVs) in a randomized, controlled trial with evaluator blinding. Participants were non-frail adults ≥ 65 y old, annually TIV-immunized. Study vaccines included intradermal (IDV), MF59-adjuvanted (ADV) and subunit (TIV) formulations of equal...

BACKGROUND Responses to influenza vaccines are poorly characterized in immunocompromised patients. The goal of this study was to assess the efficacy of the AS03-adjuvanted influenza H1N1/A/09 vaccine in allogeneic hematopoietic stem cell transplant recipients. DESIGN AND METHODS We enrolled 65 patients and 138 controls in an open prospective study. Controls received one dose and patients 2 do...

Background The prevalence of hepatitis B viral (HBV) infection in Indonesia is high. The most effective way to control HBV infection is by hepatitis B (HB) immunization. Many studies reported that hepatitis B surface antibody (anti-HBs) seroprotection declines in children > 10 years of age. In addition many factors can influence anti-HBs titer. Objective To measure anti-HBs titer and evaluate p...

The plasma derived vaccine for hepatitis B became commercially available in 1982 but its availability was limited. The new generation of hepatitis B vaccine (recombinant rDNA yeast derived) can be produced in greater quantities at a comparable cost. Recombinant HBV vaccine given in infancy is highly immunogenic. Most infants develop antibody titre well above 10 m1U/ml, the level associated with...