Venlafaxine is a newly introduced antidepressant agent. The drug causes selective inhibition of neuronal reuptake of serotonine and norepinephrine with little effect on other neurotransmitter systems. Cases of seizures, tachycardia, and QRS prolongation have been observed following drug overdose in humans. The clinical manifestations of cardiac toxicity suggest that venlafaxine may exhibit card...

BACKGROUND In major depression, one of the candidate genes possibly affecting the risk and severity of symptoms has been found to be tryptophan hydroxylase (TPH1). Variation in treatment response to antidepressive agents according to TPH1 genotype has also been found in several studies. However, the relationship between temperament and TPH1 genotype in major depression is poorly understood, as ...

This work is about interactions between facilitation and inhibition of behavioural responses. Generally, rewards elicit approach and are associated with facilitation of responses, whereas punishments elicit avoidance and inhibit behavioural responses other than fight or flight. Dopamine (DA) and serotonine (5HT) have been widely associated with respectively facilitatory and inhibitory regulatio...

Matters of sexuality and intimacy greatly impact quality of life of patients with gynecologic cancers. Vast amount of evidence exists showing that cancer dramatically impacts woman's sexuality, sexual functioning, intimate relationships and sense of self. Sexual functioning can be affected by illness, pain, anxiety, anger, stressful circumstances and medications. There is a growing acknowledgem...

ecological demands interfering with oxygen delivery such as environmental hypoxia (Butler et al., 1978; Wheatly and Taylor, 1981; McMahon, 1992; Reiber et al., 1992; Airries and McMahon, 1994), air exposure (Taylor and Wheatly, 1981; Airries and McMahon, 1996) or exercise (Herreid et al., 1983; Hamilton and Houlihan, 1992; Hokkanen and DeMont, 1992; Reiber, 1994; Reiber et al., 1997) with vario...

Amineptine is a new antidepressant agent with a molecular structure which is related to the tricyclic antidepressants but with a different pharmacological action. Neurochemical studies have shown that amineptine stimulates dopaminergic neurotransmission in the mesolimbic and mesocortical systems by inhibition of the re-uptake of dopamine at presynaptic level (Mocaer, 1983; Labril et al., 1987; ...

The sudden onset of a major neurological deficit in concomitance with the removal of a central venous line (CVL) is an unexpected finding to our knowledge not previously described. We recently observed this phenomenon in 3 of 460 consecutive patients in whom a CVL line (usually inserted in the right internal jugular vein) was used during routine cardiac surgical procedures. All 3 patients had a...

Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adeno...

Every year scores of new pharmaceuticals enter the market, almost never with human fetal safety data. Such data typically accumulate during the "rst years of clinical use, in the form of case reports, case series, prospective and retrospective cohorts and case control studies. All of these methods su#er from serious sources of bias, o$en leading to alarming signals of teratogenicity that are la...