An experiment was conducted to investigate the effect of different types of ovarian cycles on reproductive indices and blood metabolites in 61 Holstein cows. Blood samples were taken from each cow between day 12 and day 50 postpartum (PP). Serum progesterone concentrations were measured to determine the onset of luteal function and different types of luteal dysfunctions in cows. Serum glucose, ...

Oral squamous cell carcinoma is an important malignancy of epithelial origin with high rate of morbidity and mortality. While tobacco and alcohol are the primary risk factors; other factors such as microorganisms, chronic irritation and sex hormones along with underlying genetic factors may also contribute to its pathogenesis. The role of sex hormones like estrogen, progesterone and testosteron...

A relationship between formation of methylsulfonyl (MeSO2) metabolites of 2,2',4,5,5'-pentachlorobiphenyl (PentaCB) and decrease in serum thyroxine (T4) level was examined in the rats and mice after a single i.p. injection of PentaCB (342 micromol/kg body weight). In either rats or mice, levels of the 3- and 4-MeSO2 metabolites of PentaCB in the liver and feces increased in a time-dependent fas...

Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease. We prospectively investigated the association between serum metabolites measured by targeted metabolomics and risk of T2D in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (27,548 adults) among all incident cases...

keyvan karkoodi*, saeed khalajzadeh department of animal science, saveh branch, islamic azad university, saveh, iran   *corresponding author's e-mail: [email protected]   received: 12 august 2013 accepted: 21 november 2013   abstract   thirty neonatal male holstein calves fed by starter diets containing ground wheat (gw) or dry-rolled wheat (drw) to 12 weeks of age. skeletal growth ...

OBJECTIVE Patients with type 1 diabetes (T1D) with impaired renal function are at increased risk for end-stage renal disease (ESRD). Although the rate of progression varies, determinants and mechanisms of this variation are unknown. RESEARCH DESIGN AND METHODS We examined serum metabolomic profiles associated with variation in renal function decline in participants with T1D (the Joslin Kidney...

Metabolite differences between sexes have rarely been observed in a global manner, but it has recently been made possible by the advancement in metabolomics techniques. In this study, untargeted ultraperformance liquid chromatography coupled to time-of-flight mass spectrometry and an in-house software platform were used for a rapid comparison of sex differences in urinary metabolites in humans ...

Abstract Purpose The relationship between Hashimoto's thyroiditis and vitamin D concentration was already presented in many studies. aim of this study to analyze the differences metabolites healthy women with (HT). Methods quantitative analysis five carried out using liquid chromatography coupled tandem mass spectrometry. analyzed materials were serum dried blood spots (DBS). results obtained f...

BACKGROUND Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to evaluate their suitability for assessing per...

OBJECTIVE To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study. SUBJECTS AND METHODS Analyses were based on metabolite profile from 965 participants of the S4 and 890 weight-stable subjects of its seven-year follow-up study (KORA F4). 190 dif...