Natural sulfated polysaccharides (SPs) derived from brown seaweed comprise a complex group of macromolecules with a wide range of important physiological properties. SPs have been shown to bind and directly regulate the bioactivity of growth factors and cytokines such as basic fibroblast growth factor, interferon, various enzymes and transforming growth factor. Myostatin is a member of the tran...

Aging is associated with progressive loss of strength and muscle mass that this process is commonly referred to as “sarcopenia”. Decline in muscle mass and strength related to aging or sarcopenia leads to significant impairment in the ability to carry out normal daily functions and an increased risk of falls and fractures. Muscle hypertrophy is likely to result from the cumulative effects of re...

the aim of this study was to determine the effect of resistance training for 10 weeks on muscle strength, lean body mass, serum myostatin, and insulin resistance in obese-overweight men. seventeen obsess-overweight men(age:=43.1±4.7 yr, body mass index = 29.1±2.17 kg/m2) participated in the study the subjects were randomly assigned to resistance training (n=9) and control (n=8) groups. resistan...

myostatin is a growth factor belonging to the tgfß superfamily. tgfß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. mutations in coding sequences of the bovine myostatin (gdf8) gene lead to muscle hyperplasia suggesting its inhibitory function ...

Myostatin is a growth factor belonging to the TGFß superfamily. TGFß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. Myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. Mutations in coding sequences of the bovine myostatin (GDF8) gene lead to muscle hyperplasia suggesting its inhibitory function ...

Myostatin, a member of the transforming growth factor-β superfamily, has been implicated in the potent negative regulation of myogenesis in murine models. However, little is known about the mechanism(s) through which human myostatin negatively regulates human skeletal muscle growth. Using human primary myoblasts and recombinant human myostatin protein, we show here that myostatin blocks human m...

Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in the heart is controversial. Our goal in this study was to characterize myostatin regulation following cardiomyocyte stress and to examine the role of myostatin in the regulation of cardiomyocyte size. Neonatal cardiomyocytes were cultured and stressed with phenylephrine. Adenovirus was used to overe...

Myostatin is a negative regulator of muscle growth and fiber size. Changes in myostatin expression might contribute to changes in muscle mass associated with various conditions, and reducing the amount of active myostatin is a potential strategy for preventing or reversing muscle atrophy. The present study was done to determine the extent to which myostatin levels must decline to induce growth ...