An experimental model was designed to study the ability of antibiotics to enter the pericardial compartment. Noninfected and infected pericardial fluid and serum antibiotic activities were determined in adult mongrel dogs before and at intervals after antibiotic administration. After the administration of penicillin G, methicillin, cephaloridine, streptomycin, or gentamicin, clinically adequate...

BACKGROUND Inadequate intrapleural drug concentrations caused by poor penetration of systemic antibiotics into the pleural cavity is a major cause of treatment failure in empyema. Herein, we describe a novel antibiotic-eluting pigtail catheter coated with electrospun nanofibers used for the sustained release of bactericidal concentrations of penicillin in the pleural space. METHODS Electrospu...

I t has been shown in the preceding paper (1) that penicillins F, G, K, and X are all inactivated by serum, plasma, and whole blood, but at widely varying rates. Penicillin X was inactivated slowly (5 to 7 per cent per hour in 96 per cent human or rabbit serum at 37°C.); F and G somewhat more rapidly (8 to 10 per cent per hour); while the rate of inactivation of K varied with its concentration....

In continuing the study of the mode of action of penicillin, it was decided to compare the therapeutic effect of single massive doses of crystalline penicillin andof bicillin-1 (benzathine penicillin, which produces therapeutic serum levels for 2 to 4 weeks). Evaluation of the effectiveness of these two preparations was based on clinical observation of the resorption of the chancres, the disapp...

Sodium polyanethol sulfonate inhibits aminoglycoside and polymyxin classes of antibiotics in direct proportion to its concentration. Aminoglycoside and polymyxin class antibiotics are selectively inactivated; penicillin, including the semisynthetic penicillins, cephalothin, chloramphenicol, clindamycin, tetracycline, erythromycin, and vancomycin are not inhibited. By incorporating sodium polyan...

The aim of the present study was to prepare new cluster (B6C4Si) as an antibiotic carrier. Density functional theory (DFT) method at the B3LYP level of theory in conjugate with the 6-311G** basis set was used to evaluate the interaction between B6C4Si cluster and Penicillin. Binding parameters, HOMO, LUMO and HOMO- LUMO GAP were calculated. Results show the ‍ B6C4Si HOMO–LUMO gap value of 0.13...

In this study 71 head of conceiving ewe and their progeny (91 head) from the flock of Lori-Bakhtiari sheep (360 head), in Sholi Station were randomly selected to determine the relationship between the immunoglobulin (IgG) concentration in the ewe's serum and colostrum, and lamb's serum. Ewe blood sample, colostrum of ewe and blood of the lamb was taken 2 weeks before parturition, 1 to 8 hours a...

the aim of the present study was to prepare new cluster (b6c4si) as an antibiotic carrier. density functional theory (dft) method at the b3lyp level of theory in conjugate with the 6-311g** basis set was used to evaluate the interaction between b6c4si cluster and penicillin. binding parameters, homo, lumo and homo- lumo gap were calculated. results show the ‍ b6c4si homo–lumo gap value of 0.13...