OBJECTIVE To determine the pharmacokinetics of testosterone following its administration using transdermal gel or buccal lozenges. DESIGN Pilot study. SETTING University-based hospital. PATIENT(S) Ten bilaterally oophorectomized women. INTERVENTION(S) Daily micronized testosterone gel (1 mg) and testosterone propionate lozenge (1 mg). MAIN OUTCOME MEASURE(S) Total testosterone, andros...

Objective: Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome (PCOS) patients. There are various reports about hypoglycemic and antioxidant effects of Salvia officinalis L. (common sage). This study evaluated the possible medicinal effects of sage tea drinking on oxidative status, lipid profile, and insulin resistance in ...

OBJECTIVE Testosterone stimulates erythropoiesis and thus glycated hemoglobin (A1C) values may be relatively low in male diabetic patients with hypogonadism. We therefore investigated relationships between serum bioavailable testosterone concentration and the ratio of glycated albumin (GA) to A1C and between serum bioavailable testosterone and hemoglobin concentrations in men with type 2 diabet...

Objective: Testosterone stimulates erythropoiesis and thus glycated hemoglobin (HbA1c) values may be relatively low in male diabetic patients with hypogonadism. We therefore investigated relationships between serum bioavailable testosterone concentration and the ratio of glycated albumin (GA) to HbA1c as well as between serum bioavailable testosterone and hemoglobin concentrations in men with t...

BACKGROUND Data from prior studies have yielded inconsistent results on the association of serum testosterone levels with the risk for cardiovascular disease. There are no clinical trial data on the effects of testosterone replacement therapy on plaque progression. OBJECTIVE We designed a study to investigate the effect of testosterone therapy on coronary artery plaque progression using seria...

PURPOSE Late-onset hypogonadism (LOH) in aging males is a clinical and biochemical syndrome characterized by a decline in serum testosterone levels. LOH results in various physical and mental disabilities. We evaluated the relationship between serum testosterone levels and symptoms of LOH. MATERIALS AND METHODS During an andropause screening program, we examined responses to the Saint Louis u...

The goal was to evaluate the associations between testicular hormones at adolescence and the exposure to chlorination by-products when attending chlorinated swimming pools. We obtained serum samples from 361 school male adolescents (aged 14-18years) who had visited swimming pools disinfected with chlorine or by copper-silver ionization. We analysed serum concentrations of inhibin B (two differe...

BACKGROUND There are limited evaluation and treatment options for low libido in premenopausal women. This review sought to evaluate the available evidence supporting the evaluation of testosterone serum levels and testosterone treatment of premenopausal women with low libido. METHODS MEDLINE, PubMed, and ClinicalTrials.gov were searched for articles that referenced the evaluation of testoster...

OBJECTIVE The evaluation of serum sex steroids and sex hormone-binding globulin (SHBG) levels in postmenopausal women with nonalcoholic fatty liver disease (NAFLD) and their association to the disease severity. DESIGN Twenty-two postmenopausal women with biopsy-proven NAFLD and 18 matched controls were recruited. Blood samples for serum SHBG, total testosterone, estradiol levels and standard ...