To the Editor: The Department of Surgery at the Nelson R Mandela School of Medicine is proud of its 100% pass rate in the October 2008 Colleges of Medicine of South Africa examinations held in Durban. Most candidates attended the graduation and joined the 3 who passed in May as registered specialists in general surgery. This represents a stalwart effort on the part of the candidates and their t...

Ageing is acknowledged to result from a lifelong accumulation of molecular and cellular damage, caused by many mechanisms that are regulated by a complex maintenance and repair network. Multimorbidity and polypharmacy are the results of our good standard of care for ageing persons as present in many Western societies. Many healthcare expenses and efforts are currently devoted to providing healt...

Johansen and Sornette proposes that the crash has fundamentally an endogenous origin and exogenous shocks only serve as triggering factors. This endogenous force is shown in price as power law log-periodicity (PLLP) signature prior to a crash. We estimate the highly nonlinear model developed by them using a hybrid approach which combines scatter search, genetic adaptor and tabu search. The mode...