The increasing cancer-related mortality related to rapid decreases in blood pressure from the pharmacologic treatment of hypertension as seen in the Systolic Hypertension in the Elderly Program (SHEP; 1) draws interesting parallels to the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial (2). The data suggest that some common treatments used for the prevention of cardiovas...

BACKGROUND Research on the association between antihypertensive drug treatment (HTDT) and cancer is equivocal. We tested the hypothesis that large, rapid decreases in blood pressure following HTDT are associated with higher cancer mortality. METHODS Data from the Systolic Hypertension in the Elderly Program (SHEP) with 15-year cause-specific follow-up for mortality were used. We used changes ...

We take the manifestly gauge invariant exact renormalisation group previously used to compute the one-loop β function in SU(N) Yang-Mills without gauge fixing, and generalise it so that it can be renormalised straightforwardly at any loop order. The diagrammatic computational method is developed to cope with general group theory structures, and new methods are introduced to increase its power, ...

We have calculated the one-loop supersymmetric corrections to the 2 → 2 parton scattering subprocesses q̄q → q̄q, q̄q → gg, gq → gq and gg → gg, including form-factor corrections and box diagrams with internal squarks and gluinos of arbitrary mass. In general, these exhibit cusps at the corresponding direct-channel sparticle thresholds. We use these calculations to make numerical estimates of the ...

BACKGROUND Investigators have shown that depression is associated with an increased risk of coronary heart disease in general and myocardial infarction in particular. However, it is unknown whether depression, independent of its association with myocardial infarction, is a risk factor for heart failure. METHODS This study examined whether depression was a predictor of incident heart failure a...