In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol. Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol and [6...

Zingiber officinale (ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data from in vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, an...

In traditional herbal medicine, comprehensive understanding of bioactive constituent is important in order to analyze its true medicinal function. We investigated the chemical properties of medicinal and edible ginger cultivars using a liquid-chromatography mass spectrometry (LC-MS) approach. Our PCA results indicate the importance of acetylated derivatives of gingerol, not gingerol or shogaol,...

The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. A...

ginger (zingiber officinale roscoe) contains the biological properties of the major standard non–volatile pungent compounds of ginger, namely, [6]–, [8]–, and [10]–gingerols, as well as [6]– , [8]–, and [10]–shogaols. so far, the comparative antioxidant potencies among shogaols and gingerols have not been studied in detail and reported. accordingly, this study aimed to examine and compare the a...

Background: In Indonesia, the use of herbal plants in overcoming several health problems shows a fairly high rate. Red ginger is one herbs that widely consumed and empirically has property relieving or reducing inflammation. However, as well known, general microbiological contamination quite high. To maintain quality plants, special treatment required, to ensure microbial within safe limits. Th...

The aim of the present study was determine optimum processing conditions and nanoemulsion formulation for preparation gingerol shogaol from ginger extract-based subcritical water. For this purpose, nanoemulsions were prepared with rotor-stator homogenizer varied surfactant cosurfactant concentrations (24%, 26% 28% v/v), stirring speed (22,000 rpm, 24,000 rpm). time is adjusted to 30 minutes. de...