Self-injurious behavior (SIB) is a primary reason that individuals with neurodevelopmental disabilities (NDD) are either retained in restrictive environments or are administered psychotropic medication. There are no known causes and no universally accepted treatments for this complex behavior among individuals with NDD. There is developing evidence, however, that individuals exhibiting SIB have...

The term Self-injurious Behavior (SIB) represents behavioral characteristics that can damage body tissue. Persons with Intellectual Disability (ID) have a greater probability of developing inadequate behavior such as SIB. Literature indicates the presence of SIB in different syndromes. In the Prader-Willi Syndrome (PWS) the most frequent physical manifestation is skin-picking, which involves th...

SIB-1765F ([+/-]-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine fumarate) is a novel nicotinic acetylcholine receptor (NAChR) agonist displaying a different in vitro pharmacological profile than nicotine and epibatidine, suggestive of NAChR subtype selectivity. Our study describes the effects of SIB-1765F on locomotor activity in rats, which were compared to those observed for nicotine and epiba...

OBJECTIVE To test the hypothesis that self-injurious behavior (SIB) signals an attempt to cope with psychological distress that may co-occur or lead to suicidal behaviors in individuals experiencing more duress than they can effectively mitigate. DESIGN Analysis of a cross-sectional data set of college-age students. SETTING Two universities in the northeastern United States in the spring of...

Social Impact Bonds (SIBs), also known as Pay-for-Success, are an innovation in Payment by Results contracting. Investors finance programs and repaid based on the “SIB effect,” which includes changes outcomes attributable to financing. We generate a quantitative estimate of this part SIB effect for two active labor market Netherlands Switzerland. Comparing program impacts within providers using...

We examined the relation between stereotyped behavior and self-injurious behavior (SIB) for 1871 individuals with intellectual disabilities who had a score of >0 on the Behavior Problem Inventory (BPI-01; Rojahn et al., 2001). We report three main findings: First, structural equation modeling techniques (SEM) revealed that the BPI-01stereotyped behavior subscale scores predicted BPI-01 SIB subs...

The sequences encoding the QUAD1 RNAs were initially identified as four repeats in Escherichia coli. These repeats, herein renamed SIB, are conserved in closely related bacteria, although the number of repeats varies. All five Sib RNAs in E. coli MG1655 are expressed, and no phenotype was observed for a five-sib deletion strain. However, a phenotype reminiscent of plasmid addiction was observed...

Serpula himantioides (Boletales, Basidiomycota) produces thin resupinate basidiocarps on dead coniferous wood worldwide and causes damage in buildings as well. In this study, we present evidence for the existence of at least three phylogenetically defined cryptic species (referred to as Sib I-III) within the morphospecies S. himantioides, a conclusion based on analyses of sequence data from fou...

Operant and biological theories of the cause of self-injurious behavior (SIB) in people with a mental handicap are often viewed as mutually exclusive. In this single case study, interactions between features of Rett syndrome and operant conditioning as determinants of SIB are examined. Functional analysis by analog methodology indicated different functions for two forms of SIB shown by the subj...

Self-injurious behavior (SIB) is a broad term describing a behavior that causes (or potentially produces) physical harm to oneself. This behavior is described in individuals intellectual and developmental disabilities, including those with autism. SIB is a severe clinical condition that produces serious medical consequences and limits life opportunities for the persons and those who care for th...