A 35-year-old man was admitted to hospital with severe anemia. Two years back, he had presented with bleeding esophageal varices and subsequently diagnosed as a case of chronic liver disease with portal hypertension. He was then treated with esophageal band ligation. He tested positive for hepatitis B surface antigen with HBV DNA levels of 4 × 106 copies/ml by PCR. His repeat endoscopy showed g...

Mice carrying two mutant genes at the f locus on chromosome 1 3 have severe anemia during fetal development, characterized by hypochromic and microcytic red blood cells laden with many iron granules. Ultrastructural studies reveal that the cxcessive nonheme iron accumulated in mutant ( f/f ) fetal erythrocytes is present within mitochondria, similar to those seen in human sideroblastic anemia. ...

Ring sideroblasts Ring sideroblasts are erythroblasts with iron-loaded mitochondria visualized by Prussian blue staining (Perls’ reaction) as a perinuclear ring of blue granules (Figures 1D and 2C). The International Working Group on Morphology of Myelodysplastic Syndrome (IWGM-MDS) recommended that ring sideroblasts be defined as erythroblasts in which there are a minimum of five siderotic gra...

N ASSOCIATION BETWEEN megaloblastic anemia and therapy for tuberculosis has been described previously in five instances.1-3 In three patients megaloblastic erythropoiesis was associated with sideroblastic changes in the bone marrow,1’2 and in two the megaloblastic anemia was attributed .o deficiency of vitamin B12 resulting from malabsorption of this vitamin induced by therapy with para-amirios...