BACKGROUND To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement. METHODS We performed a single-center, open-label, single-arm, post-marketing interventional clinical trial. Inclusion criteria were: Caucasian subjects age...

Abstract A capillary gas chromatographic method using flame ionization detection was developed and validated for the trace quantification of 2-bromoethanol (2-BE) 2-bromoethylmethanesulfonate (2-BEM) in silodosin, used treatment benign prostatic hyperplasia. Chromatographic separation performed spilt mode nitrogen as carrier on a column containing crosslinked polyethylene glycol (30 m × 0.32 mm...

Objectives To evaluate the impact of silodosin on stages flexible ureteroscopy (F-URS) procedures, complications, and stone-free rate (SFR).Patients Methods A prospective, randomized, controlled comparison research was conducted 106 patients who were randomly allocated into two groups: study group (52 patients) received F-URS with preoperative daily uptake 8 mg for 10 days, control (54 F- URS w...

Naftopidil, approved only in Japan, is an α1-adrenergic receptor antagonist (α1-blocker) used to treat lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Different from tamsulosin hydrochloride and silodosin, in that it has higher and extremely higher affinity respectively, for the α1A-adrenergic receptor subtype than for the α1D type, naftopidil has distinct ...

Researchers are constantly seeking ways to improve existing drugs, drug mechanisms of activity, find new indications for old drugs or to develop new drugs to treat urological diseases and conditions. In Canada, tadalafil in a 5 mg daily dosage (old drug), and a new drug, silodosin, have recently become available to treat patients who have benign prostatic hyperplasia (BPH) with lower urinary tr...

Abstract Background Alpha-blockers prescribed as medical expulsion therapy (MET) have replaced minimally invasive procedures the primary line of treatment for minor ureteric stones. This study aims to investigate efficacy MET with alpha-blockers in terms stone rate and time evaluate safety several alpha-blockers. Methodology Google Scholar, PubMed, Web Science databases were searched relevant p...