Software simulations are presented for the magnetic and optical recording channels that illustrate the performances, measured in bit error rate (BER) dependence by signal to noise rate (SNR) characteristics of recording digital sequences, calculated for equalized partial response channels followed by Viterbi detection versus decision feedback equalization followed by fixed depth tree search det...

Making and holding an artificial lipid bilayer horizontally in an aqueous solution within the microscopic working distance of ~100 μm are essential for simultaneous single molecule imaging and single ion-channel electrical current recording. However, preparation of such a lipid bilayer without a solid support is technically challenging. In a typical supported lipid bilayer, the asymmetric local...

Devor, Daniel C., and Raymond A. Frizzell. Modulation of K1 channels by arachidonic acid in T84 cells. II. Activation of a Ca21-independent K1 channel. Am. J. Physiol. 274 (Cell Physiol. 43): C149–C160, 1998.—We used singlechannel recording techniques to identify and characterize a large-conductance, Ca21-independent K1 channel in the colonic secretory cell line T84. In symmetric potassium gluc...

Patch-clamp recordings of single-channel activity are measurements of the current flowing through an ion channel over time. These recordings are distinctive, because they generally show sudden transitions between two welldefined levels of current flow. The two levels of current flow are normally interpreted as representing closed and open states of an ion channel. The transitions appear to be s...

Orai1 comprises the pore-forming subunit of the Ca(2+) release-activated Ca(2+) (CRAC) channel. When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. We have developed an approach ...

The topics of this thesis are the mathematical models of the magnetic recording channel and their ultimate information-theoretic limit, the capacity. Source and channel of a magnetic recording system can be represented by a single finitestate model (FSM). The joint source/channel FSM is fully specified by the state-transition probabilities of the source model and the output probability distribu...

Introduction: Previous studies and our works have indicated several cation channels in the rat brain mitochondrial inner membrane. In this work, we report the single-channel characterization of a cation channel from the rat brain mitochondrial inner membrane incorporated into a planar lipid bilayer. Methods: After removing and homogenizing the adult rat brain, its supernatant was centrifuged...

Artemisia annua L. belongs to the Asteraceae family, which is indigenous to China. It has valuable pharmacological properties, such as antimalarial, anti-inflammatory, and anticancer properties. However, whether it possesses antiasthma properties is unknown. In the current study, chloroform extract of Artemisia annua L. (CEAA) was prepared, and we found that CEAA completely eliminated acetylcho...