نتایج جستجو برای: siv
تعداد نتایج: 3091 فیلتر نتایج به سال:
The primary immune response to M. leprae was therefore studied in rhesus monkeys with advanced SIV infection, and in SIV [-] controls. The percentages of CD4+ and CD8+ T cells were determined over 63 days postinoculation in blood and in cutaneous inoculation sites of live M. leprae and compared with flowcytometric determinations of CD4 and CD8 levels in peripheral blood and with assessment of M...
It has been established that many simian immunodeficiency virus (SIV) isolates utilize the orphan receptors GPR15 and STRL33 about as efficiently as the chemokine receptor CCR5 for entry into target cells. Most studies were performed, however, with coreceptors of human origin. We found that SIV from captive rhesus macaques (SIVmac) can utilize both human and simian CCR5 and GPR15 with comparabl...
Resting CD4+ T cells are a reservoir of latent HIV-1. Understanding the turnover of HIV DNA in these cells has implications for the development of eradication strategies. Most studies of viral latency focus on viral persistence under antiretroviral therapy (ART). We studied the turnover of SIV DNA resting CD4+ T cells during active infection in a cohort of 20 SIV-infected pigtail macaques. We c...
We studied the occurrence of swine influenza virus (SIV) infection in piglets with respiratory symptoms resembling porcine respiratory disease complex (PRDC). A total of 106 samples including nasal swab and lung suspension from sick piglets were collected from 30 farms of medium size in the central and eastern parts of Thailand from August 2006 to February 2007. Samples were inoculated onto Mar...
Pathogenic simian immunodeficiency virus (SIV) infection is associated with enteropathy, which likely contributes to AIDS progression. To identify candidate etiologies for AIDS enteropathy, we used next-generation sequencing to define the enteric virome during SIV infection in nonhuman primates. Pathogenic, but not nonpathogenic, SIV infection was associated with significant expansion of the en...
BACKGROUND Non-human primates infected with simian immunodeficiency virus (SIV) represent a robust model to evaluate pre-clinical efficacy of HIV-1 preventive strategies and to determine the size of reservoir. METHODS We developed a real-time qPCR assay to specifically quantify episomal 2-LTR circular DNA in peripheral blood mononuclear cells and brain tissues from SIV-infected macaques. RE...
In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (10(3) 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, t...
To assess human exposure to Simian immunodeficiency virus (SIV) in west central Africa, we looked for SIV infection in 788 monkeys that were hunted in the rainforests of Cameroon for bushmeat or kept as pets. Serologic reactivity suggesting SIV infection was found in 13 of 16 primate species, including 4 not previously known to harbor SIV. Overall, 131 sera (16.6%) reacted strongly and an addit...
PIXE studies of normal and SIV-infected rhesus macaque tissues: investigations of particulate matter
Abstract Positron Emission Tomography (PET) studies [1] of the evolution Simian Immunodeficiency Virus (SIV) (the monkey analogue Human (HIV) have revealed that SIV is localised in different organs at stages infection. Promising routes to completely eradicate HIV virus particles involve therapies target infection cellular level. Our previous μ -Particle Induced X-ray ( μ- PIXE) very large varia...
This systematic review and meta-analysis summarises the literature on parental acceptance, hesitancy, uptake, associated factors of seasonal influenza vaccination (SIV) among children aged 6–59 months. Studies were sourced from following platforms: PubMed, Web Science, MEDLINE, EMBASE databases. A random-effects model was used to evaluate prevalence 95% confidence intervals (CI) SIV uptake in l...
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