introduction: in this study, we intend to use diffuse optical tomography (dot) as a noninvasive, safe and low cost technique that can be considered as a functional imaging method and mention the importance of image reconstruction in accuracy and procession of image. one of the most important and fastest methods in image reconstruction is the boundary element method (bem). this method is introdu...

In Europe, hydroquinone is a forbidden cosmetic ingredient. It is, however, still abundantly used because of its effective skin-whitening properties. The question arises as to whether the quantities of hydroquinone used become systemically available and may cause damage to human health. Dermal absorption studies can provide this information. In the EU, dermal absorption has to be assessed in vi...

Monitoring of tissue blood volume and local oxygen saturation can inform the assessment of tissue health, healing, and dysfunction. These quantities can be estimated from the contribution of oxyhemoglobin and deoxyhemoglobin to the absorption spectrum of the dermis. However, estimation of blood related absorption in skin can be confounded by the strong absorption of melanin in the epidermis and...

In order to obtain better insight into the robustness of in vitro percutaneous absorption methodology, the intraand interlaboratory variation in this type of study was investigated in 10 European laboratories. To this purpose, the in vitro absorption of 3 compounds through human skin (9 laboratories) and rat skin (1 laboratory) was determined. The test materials were benzoic acid, caffeine and ...

Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm(2)/h for 20 microl/cm(2) and 40 microl/cm(2), respectively. Similar results were observed after in vitro topical application of neat...

1. The removal of the beta(2)A-globulins from three sera from treated ragweed-sensitive individuals by immune absorption was associated with the loss of all detectable skin-sensitizing antibody activity as demonstrated by Prausnitz-Küstner testing. 2. Gel filtration studies, with sephadex G-200, indicated that the fractions containing only macroglobulins were devoid of all detectable skin-sensi...

The permeability of the skin of newborn infants to lignocaine was examined in vitro using excised skin. Samples were studied from 24 infants of gestational age 25 to 40 weeks and postnatal age 0 to 7 days. Mature skin was relatively impermeable to lignocaine, but the more premature infants showed a marked increase in absorption. There was a strong inverse correlation between gestational age and...

Transdermal absorption of flurbiprofen (FP) from a cataplasm (CFP) and its antiinflammatory effect were investigated in the rat under various skin temperature conditions. As the skin temperature was raised, the plasma concentration of FP after application of the cataplasm increased significantly. It was demonstrated by a release and in vitro penetration experiment that skin penetration is the r...