Arsenical keratosis and skin cancer are among the most common health effects associated with acute and chronic exposures to arsenic. This study examines the acute and chronic dose-responses of arsenic in established human cell lines using keratinocytes (HaCaT), melanocytes (CRL1675) and dendritic cells (THP-1 + A23187). Chronic conditions were established by treating the three cell lines with a...

Aryl hydrocarbon hydroxylase of mouse skin is inducible by benz(a)anthracene or 7,12-dimethylbenz(a)anthracene (DMBA) and is inhibited by 7,8-benzoflavone. 7,8-Benzo flavone inhibits the formation of covalently bound complexes of DMBA with DNA, RNA, and protein and also inhibits tumor formation caused either by a single application of DMBA, followed by croton oil treatment, or by the repeated a...

objective(s):involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. materials and methods: in the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (-)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (-)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (-)-bornesit...

disease, and in other lymphomas. Patients with leukemia and lymphoma, but not carcinomas, also reacted with extracts of tumor-derived lymphoid cell lines. Studies of in vitro cell-mediated cytotoxicity against autologous tumor cells, using the 51Cr release assay, also gave evidence for reactivity against tumor-associated antigens. In humoral and cell-mediated cytotoxicity assays against lymphoi...

Acyclovir (ACV) is a promising candidate for drug repurposing because of its potential to provide an effective treatment viral infections and non-viral diseases, such as cancer, which limited options exist. However, poor physicochemical properties limit application. This study aimed formulate evaluate ACV-loaded red clay nanodrug delivery system exhibiting cytotoxicity. The focused on the prepa...

Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and p...

Cosmetic patches have recently been developed as skin products for personal care owing to rapid advances in the technology of delivery of active ingredients, moisture, and adhesiveness to skin. Alginate and Spirulina are typical marine resources used in cosmetic products. This research involved the development of a Spirulina extract-impregnated alginate nanofiber cosmetic patch supported by a p...