In this study a new approach to laser tattoo removal is proposed. Although Qswitched laser systems have become the gold standard in tattoo removal, they also have their limitations. To overcome existing procedure limits, pretreatment conditioning of the skin with a fractional Er:YAG laser was studied. Laserdrilled micro channels known as skin perforations were found to enhance the efficacy o...

<p><strong>Background:</strong> In the genetic skin blistering disorder dystrophic epidermolysis bullosa recurrent blisters and erosions on mechanically stressed areas, as hands, result in subsequent scarring development of pseudosyndactylies contractures. its most severe form, all fingers are constrained into a fist scarred (“mitten-hand”-deformity). No causative therapy exis...

BACKGROUND Better delivery systems are needed for routinely used vaccines, to improve vaccine uptake. Many vaccines contain alum or alum based adjuvants. Here we investigate a novel dry-coated densely-packed micro-projection array skin patch (Nanopatch™) as an alternate delivery system to intramuscular injection for delivering an alum adjuvanted human papillomavirus (HPV) vaccine (Gardasil®) co...

Titanium micro-mesh implants are widely used in orbital wall reconstructions because they have several advantageous characteristics. However, the rough and irregular marginal spurs of the cut edges of the titanium mesh sheet impede the efficacious and minimally traumatic insertion of the implant, because these spurs may catch or hook the orbital soft tissue, skin, or conjunctiva during the inse...

BACKGROUND AND OBJECTIVES Various methods have been suggested to enhance photon density in biological tissues in an attempt to maximize the efficacy of laser therapy. In this study, the effects of tissue compression, glycerol, and micro-needling methods on the laser beam profile (LBP) were investigated by quantitatively evaluating the spatial distribution of subsurface tissue photon density. ...

Scaffold-like surfaces, ranging from large-scale trusses to engineered micro-structures, are often sketched via repeating patterns of nodes and edges. Offsetting these graphs turns them into meshes for which a smoothly-rounded scaffold surface ‘skin’ needs be locally generated on the fly production or analysis. We focus minimal single-valence (MSV) quad whose irregular vertices all have same va...

BACKGROUND AND OBJECTIVES Fractional photothermolysis produces micro-islands of thermal injury to the skin while preserving areas among treated tissue sites in order to promote wound healing. Histological changes associated with single and multiple passes of the 1540-nm Er:Glass fractional laser were examined using in vivo human skin. METHODS AND MATERIALS Panni of five abdominoplasty patient...

Stimulated Raman scattering microscopy was used to assess the permeation of topically applied drugs and formulation excipients into porcine skin. This chemically selective technique generates high-resolution 3D images, from which semi-quantitative information may be elucidated. Ibuprofen, applied as a close-to-saturated solution in propylene glycol, was directly observed to crystallise in/on th...