purpose: to investigate the effects of sodium bicarbonate (nahco3) on exhaustive activity and physiological parameters of fatigue in conscripts. materials and methods: thirty conscripts did wingate test in two groups: sodium bicarbonate group (treatment) and placebo (control) group. in both groups, sodium bicarbonate (0.3 g/kg of body mass) or placebo was ingested 60 minutes before the training...

PURPOSE To examine the effect of beta-alanine only and beta-alanine with sodium bicarbonate supplementation on 2,000-m rowing performance. METHODS Twenty well-trained rowers (age 23 ± 4 y; height 1.85 ± 0.08 m; body mass 82.5 ± 8.9 kg) were assigned to either a placebo or beta-alanine (6.4 g · d(-1) for 4 weeks) group. A 2,000-m rowing time trial (TT) was performed before supplementation (Bas...

in order to study of effects of sodium bicarbonate on lameness occurrence and the performance of feedlot cattle, 100 holstein bull calves (251.75 ± 5.75) were used in a completely randomized design. calves were group fed a similar basal diet during 42 days experimental period. used treatments included 1) control treatment without feed additive, and 2) experimental diet that calves consumed 50 g...

Phenobarbital produces its anti-epileptic actions by increasing the inhibitory drive of γ-aminobutyric acid. However, following recurrent seizures, γ-aminobutyric acid excites neurons because of a persistent increase of chloride raising the important issue of whether phenobarbital could aggravate persistent seizures. Here we compared the actions of phenobarbital on initial and established ictal...

Sodium bicarbonate is administered during cardiopulmonary resuscitation (CPR) for the treatment of systemic acidemia. However, the effect of administering standard-dose sodium bicarbonate on the vasopressor effect of epinephrine is unknown. This study compared the effects of sodium bicarbonate or normal saline on the vasopressor effect of epinephrine in 18 pigs. After 10 minutes of unassisted v...

The hyperbicarbonatemia of chronic respiratory acidosis is maintained by enhanced bicarbonate reabsorption in the proximal tubule. To investigate the cellular mechanisms involved in this adaptation, cell and luminal pH were measured microfluorometrically using (2",7')-bis(carboxyethyl)-(5,6)-carboxyfluorescein in isolated, microperfused S2 proximal convoluted tubules from control and acidotic r...

CONTEXT Contrast-induced nephropathy remains a common complication of radiographic procedures. Pretreatment with sodium bicarbonate is more protective than sodium chloride in animal models of acute ischemic renal failure. Acute renal failure from both ischemia and contrast are postulated to occur from free-radical injury. However, no studies in humans or animals have evaluated the efficacy of s...

in order to comprise the effects of sodium bicarbonate supplementation on anaerobic performance and some plasma metabolites, 16 young male athletes (age 20.58?3.25, height 175.33?2.48 cm and bmi 21.57? 2.68 kg/m2) participated in two 400 m running sessions one hour following sodium bicarbonate or placebo (calcium bicarbonate) supplementation with the counterbalanced order. there were three bloo...