BACKGROUND FUS1 is a tumor suppressor gene located on human chromosome 3p21.3. Frequent loss of FUS1 protein expression is associated with lung cancer development. This study examined FUS1 expression and its possible tumor-suppressive role in bone and soft tissue sarcomas. MATERIALS AND METHODS The expressions of FUS1 mRNA and FUS1 protein were assessed in sarcoma cell lines, sarcoma tissues,...

INTRODUCTION Soft tissue sarcoma accounts for less than 1% of all malignant neoplasms and is comprised of a very heterogeneous group of tumors with over 50 different subtypes. Due to its diversity and rarity, developing new therapeutics has been difficult, at best. The standard of care in the treatment of advanced and metastatic disease over the last 30 years has been doxorubicin and ifosfamide...

Soft tissue sarcoma is a malignant connective tissue tumor that may arise anywhere in the body and from diverse mesenchymal elements. Its incidence is approximately 30 per million persons. The majority of patients with soft tissue sarcoma present with potentially life-threatening disease, and complete resection to obtain specimen margins free of tumor and radiation offer the best chance for loc...

Abstract Objective The relationship between the adolescent and young adult age groups poor overall survival in soft tissue sarcoma risk factors for outcomes patients with were analyzed. Methods medical records of 7759 Japanese diagnosed from 2006–13 accessed Bone Soft Tissue Tumor registry. epidemiological features compared those other groups. cancer rates calculated using Kaplan-Meier method. ...

Background The preclinical development of anti-sarcoma drugs has been primarily based on the subcutaneous transplantation of xenografts. Transplant survival remains an obstacle of current models which has been attributed to the period of hypoxia after transplantation. We hypothesized that primary soft tissue sarcoma models with an intrinsic tissue engineered vascular supply would be easily repr...

BACKGROUND Combination therapy with gemcitabine and docetaxel has been reported to be a good therapeutic strategy for patients with soft tissue sarcoma. The aim of the present study was to analyze the efficacy and toxicity of gemcitabine with docetaxel in Japanese patients with advanced bone and soft tissue sarcoma. PATIENTS AND METHODS We retrospectively analyzed the effect of gemcitabine an...

PURPOSE To evaluate the characteristics of highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis. MATERIALS AND METHODS The clinical and radiological characteristics of 18 cases of highly malignant soft tissue sarcomas of the extremity with a delayed diagnosis were determined. RESULTS Ten men and eight women of mean age 44.8 years (range, 15-79 years) were included ...

rhabdomyosarcomas are the most common soft tissue sarcoma in adult and children that accompany with skeletal muscle differentiation. skin metastasis of rhabdomyosarcomas is unusual and has only been sporadically reported in literature. in this paper we present a case of skin metastasis of rhabdomyosarcoma in an 8-year-old girl that has treated with chemotherapy.

Correspondence: Katherine A Thornton Sidney Kimmel Comprehensive Cancer Center at The Johns Hopkins University, Baltimore, MD, USA Email [email protected] Introduction: Soft tissue sarcoma accounts for less than 1% of all malignant neoplasms and is comprised of a very heterogeneous group of tumors with over 50 different subtypes. Due to its diversity and rarity, developing new therapeutics has ...

Secondary malignancy arising following brachytherapy for prostate cancer is rare in medical literature. We present a case of post-brachytherapy soft tissue sarcoma in the pelvis approximately 7 years after 103-P permanent seed implant. The patient developed a large left pelvic mass associated with significant left leg pain. He was not a good candidate for radical surgery, chemotherapy, or re-ir...