background: nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation.  the role of allergy and ige in pathogenesis of nasal polyps is still unclear.  ige receptors are important components of the immunological pathway in allergic and inflammatory diseases.   objective: to determine if the low affinity ige receptor (cd23) is presented on nasal polyp t...

CD23, the low affinity receptor for immunoglobulin E (IgE), has been proposed to play a critical role in the regulation of IgE production, based on altered IgE levels in CD23-deficient mice and transgenic mouse models, as well as in mouse strains with mutations in the CD23 gene, e.g. 129 substrains. Here, we have investigated a mouse line termed LxT1 that expresses reduced CD23 surface levels o...

Complement receptor II (CD21) is the receptor for C3d fragments on immune complexes. It also serves as a receptor for Epstein-Barr virus (EBV) and on B-lymphocytes CD21 amplifies signalling through the B cell receptor. CD21 is shed from the surface of the cell and is found circulating in plasma. There, soluble CD21 (sCD21) binds to CD23 and complement fragments, thereby modulating the immune re...

Serum soluble CD23 (sCD23) and soluble IL-2 receptor (sIL-2R) levels increase not only in disorders with immune system activation, but also in hematological malignancies. They have been used as markers of disease progression and/or the response to therapy in lymphoproliferative disorders (LPD). In this study, we investigated the serum sCD23 and sIL-2R levels of 21 patients with different hemato...

Background: Nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation.  The role of allergy and IgE in pathogenesis of nasal polyps is still unclear.  IgE receptors are important components of the immunological pathway in allergic and inflammatory diseases. Objective: To determine if the low affinity IgE receptor (CD23) is presented on nasal polyp tis...

Mice immunized with IgE/Ag complexes produce significantly more Ag-specific Abs than mice immunized with Ag alone. The enhancement is mediated via the low-affinity receptor for IgE (FcepsilonRII or CD23), as shown by its complete absence in mice pretreated with mAbs specific for CD23 and in CD23-deficient mice. Because the constitutive expression of murine CD23 is limited to B cells and follicu...