SEAWAT is a finite-difference computer code designed to simulate coupled variabledensity ground water flow and solute transport. This paper describes a new version of SEAWAT that adds the ability to simultaneously model energy and solute transport. This is necessary for simulating the transport of heat and salinity in coastal aquifers for example. This work extends the equation of state for flu...

1. Introduction Ultrafiltration is used for protein concentration and buffer exchange in the downstream processing of essentially all recombinant protein products [1]. Although ultrafiltration has traditionally been viewed as a convective pressure-driven process, with the separation determined on the basis of size, solute transport through ultrafiltration membranes is also strongly influenced b...

We consider materials with large pores interconnected by thin long channels saturated with an incompressible fluid. In the absence of fluid flow, solute transport in the porous network is diffusion controlled, however, solute transport can be enhanced when the porous network is subjected to a cyclic flow with zero time average velocity. We develop a mathematical model to analyze this physical p...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

MRP1 (multidrug resistance protein 1) couples ATP binding/hydrolysis at its two non-equivalent NBDs (nucleotide-binding domains) with solute transport. Some of the NBD1 mutants, such as W653C, decreased affinity for ATP at the mutated site, but increased the rate of ATP-dependent solute transport. In contrast, other NBD1 mutants, such as K684L, had decreased ATP binding and rate of solute trans...

The potential use of a nonlinear deterministic framework for understanding the dynamic nature of solute transport processes in subsurface formations is investigated. Time series of solute particle transport in a heterogeneous aquifer medium, simulated using an integrated probability/Markov chain (TP/MC) model, groundwater flow model, and particle transport model, are studied. The correlation di...

We present a three-dimensional framework for the transport of neutral solute through soft biological tissue, such as the articular cartilage, under different mechanical loading conditions. The tissue is modelled as a mixture of three phases, a hyperelastic, anisotropic solid matrix, an incompressible inviscid fluid and a solute. The formulation accounts for the anisotropic interaction between t...

A mathematical model for solute distribution within the tissue due to combined processes of diffusion and convective transport through the tissue, through the capillary wall, and by lymphatic absorption, during the exchange of the solute between an organ and external medium is applied for the description of the transport of small, middle and macro molecules. The analytical solutions of the tran...

A mathematical model of an absorbing leaky epithelium is developed for analysis of solute coupled water transport. The non-charged driving solute diffuses into cells and is pumped from cells into the lateral intercellular space (lis). All membranes contain water channels with the solute passing those of tight junction and interspace basement membrane by convection-diffusion. With solute permeab...

David J. Hill (corresponding author) Barbara S. Minsker Albert J. Valocchi Department of Civil and Environmental Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA Tel: +1 (217) 714 3490 Fax: +1 (217) 333 6968 E-mail: [email protected] Vladan Babovic Department of Civil Engineering, National University Singapore, 1 Engineering Drive 2, E1A 07-03, Singapore 117576 Maarten...