The crude extract of Carthamus oxycantha (Co.Cr) was studied in vitro for its possible spasmogenic and spasmolytic activities. Segments of isolated rabbit jejunum 2-3 cm long were mounted in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide. Isotonic responses were measured on Bioscience oscillograph. Isotonic responses were measured on Bioscience oscillograph. Co.Cr caused dose-d...

Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug (NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administration to structurally related pyrazolone compounds. Apart from its analgesic effect, the medication...

Background and Aims: Our previous study has demonstrated that essence of Carum copticum reduces contraction activity of ileum in rat. The present study was designed to find out the effects of nonpolar fraction of Carum copticum essence (NFCCE) on mechanical activity of the isolated ileum in rat. Materials and Methods: For evaluation of spasmolythic property of fraction, different doses of the ...

INTRODUCTION Melissa officinalis is a medical and aromatic plant that is used for its hypnotic, sedative, and spasmolytic effects. This report presents a case study of30-year-old patient who was admitted to an emergency department with restlessness, tremor, distractibility, and sweating following a discontinuation of Melissa officinalis consumption. CASE REPORT In this case, withdrawal sympto...

Achillea santolina, Nepeta cataria and Salvia bucharica are mainly known to possess antispasmodic use in traditional medicine. The essential oils from these plants were screened for their possible pharmacological activity with possible mode of action explored. Volatile oil was extracted by steam distillation using standard procedure given in British Pharmacopoeia 2001. For pharmacological activ...