نتایج جستجو برای: specific recombinase
تعداد نتایج: 1038905 فیلتر نتایج به سال:
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initiation of V(D)J recombination at antigen receptor loci. However, little is known about when during hematopoietic development the V(D)J recombinase is first active, nor is it known what elements activate the recombinase in multipotent hematopoietic progenitors. Using mice that express a fluorescent ...
We have determined the X-ray crystal structures of two DNA Holliday junctions (HJs) bound by Cre recombinase. The HJ is a four-way branched structure that occurs as an intermediate in genetic recombination pathways, including site-specific recombination by the lambda-integrase family. Cre recombinase is an integrase family member that recombines 34 bp loxP sites in the absence of accessory prot...
Supplementary Figure 1. Schematic representation and dose-response curves of different recombinase switches. a | Mechanistic illustration of the underlying recombination processes indicating the region of interest (ROI) being modified by a recombinase and the site-specific recombination sites (blue triangles). b | Detailed description of the recombinase switches. In order to express a target ge...
The mechanism controlling cell-specific Ang II production in the brain remains unclear despite evidence supporting neuron-specific renin and glial- and neuronal-specific angiotensinogen (AGT) expression. We generated double-transgenic mice expressing human renin (hREN) from a neuron-specific promoter and human AGT (hAGT) from its own promoter (SRA mice) to emulate this expression. SRA mice exhi...
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