PURPOSE We reported previously the first randomized study of any kind in patients with nonmetastatic, castrate-resistant prostate cancer. The study employed vaccine, the hormone nilutamide, and the combined therapy (crossover for each arm) with an endpoint of time to progression. We now report survival analyses at 6.5 years from the initiation of therapy with a median potential follow-up of 4.4...

introduction: breast cancer is one of the most common cancers among women. one complication after mastectomy following breast cancer is ipsilateral upper extremity lymphedema. this study aims to compare the effect of complex decongestive physical (cdp) therapy with a combination of intermittent pneumatic compression pump and cdp therapy on secondary upper extremity lymphedema volume and quality...

torture entails the deliberate infliction of severe physical and mental pain and suffering through cruel, inhuman, or degrading treatment and punishment to silence individuals and oppositions to the ruling authorities. such victims experience mental death, difficulties in coping, memory and concentration impairment, loss of core beliefs, feelings of shame and guilt, mental defeat, and alienatio...

Background:  Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) molecules are expressed on T-cells and inhibit their function by inhibiting activation of subsequent T-cell molecular pathways. Blocking of CTLA-4 inhibits the growth of malignant tumor cells. Anti-CTLA-4 monoclonal antibodies activate the immune system against cancer. Due to several advantages of single-chain antibodi...

The purpose of the present survey was to review the important Non-pharmacologic treatments for fear of flying up to the present. This study is in the same way as some studies. Accordingly, some Non-pharmacologic treatments for fear of flying were assessed through this systematic review article. The general conclusion from the information provided by the  former studies, shows that a growing num...

gene therapy consists of the introduction of genetic material into cells for a therapeutic purpose. the understanding of the basics of the molecular and cellular mechanisms in disease treatments has resulted in the development of high-tech gene transfer materials with improved therapeutic efficacy. based on the results of more than 2000 clinical trials to date, gene therapy is going to be inclu...