Background Interleukin-15 (IL-15) mediates the function of some innate and adaptive immune cells, which makes it an attractive target as an anti-cancer agent. Gene electrotransfer (GET) has been used to safely deliver plasmid DNA (pDNA) to tissues in a number of pre-clinical and clinical studies for cancer therapy. Previously we have shown using GET to deliver interleukin-15 (IL-15) to mouse me...

SIR—The concept of ‘frailty’ has been used to identify older adults at increased risk for disability [1, 2]. A major obstacle to developing primary prevention strategies for frailty is the lack of clinical markers of early frailty, especially among high functioning older adults. The Physical Performance Battery (PPB) has been reported to predict disability in older adults [3, 4], but its associ...

A measurement of gravitational wave (GW) propagation speed is one of important tests of gravity in a dynamical regime. We report a method to measure the GW propagation speed by directly comparing arrival times of GWs, neutrinos from supernovae (SN), and photons from short gamma-ray bursts (SGRB). We found that the future multimessenger observations can test the GW propagation speed with the pre...

SUMMARY 1. The agamid lizard Stellio stellio L. accelerates quickly and reaches maximum speed over short distances. 2. Maximum speed on the level is proportional to body mass to the ^ power. This relation differs from predictions based on an interspecific scaling model of "geometric" similarity (M°) and is intermediate between predictions based on interspecific scaling models of "elastic" simil...

PURPOSE The objective of this study was to describe spatial and temporal parameters during gait in pregnant women, and to compare it with women in post-partum and with a control group. METHODS To investigate alteration in natural locomotion, we used an electronic walkway (GAITRite system). Fifty-eight pregnant women (four last months of pregnancy), nine post-partum women and twenty-three heal...

Several papers in the BJPsych this month present findings that challenge accepted notions in psychiatry, and one paper focuses specifically on the extent to which the findings of highly cited papers are subsequently replicated. Tajika et al (pp. 357–362) identified highly cited studies claiming evidence of effective treatments reported in a range of high-impact general medical and psychiatric j...

Gunnell et al (pp. 298–305) investigate whether the established association between impaired intellectual performance and schizophrenia is due to the confounding influence of adverse prenatal and early childhood exposures on both intellectual development and the risk of schizophrenia. By studying a large cohort of Swedish male conscripts, results show that the association is not explained by ce...

This study investigates the relation between walking speed and the distribution of peak plantar pressure and compares a traditional ten-region subsampling (10RS) technique with a new technique: pedobarographic statistical parametric mapping (pSPM). Adapted from cerebral fMRI methodology, pSPM is a digital image processing technique that registers foot pressure images such that homologous struct...

Background & Aims: Today, different imaging techniques have been studied in the reading of radiationsensitive polymer gels dosage. Due to limitations of imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT), ultrasound techniques are proposed for dose-dependent parameter extraction. In this study, using MAGIC-f (methacrylic and ascorbic acid in gelatin initiat...