BACKGROUND Irradiation or chemotherapy that suspend normal spermatogenesis is commonly used to treat various cancers. Fortunately, spermatogenesis in many cases can be restored after such treatments but knowledge is limited about the re-initiation process. Earlier studies have described the cellular changes that happen during recovery from irradiation by means of histology. We have earlier gene...

We showed previously that testosterone (T) alone could induce spermatogenesis and produce normally fertile spermatozoa in the absence of circulating gonadotropins. These studies used the hpg mouse, which is characterized by a congenital gonadotrophin deficiency due to a major deletion in the GnRH gene. Administering T by a subdermal implant of a SILASTIC brand tube impregnated with crystalline ...

objective: animal model studies have shown that msy2 and jhdm2a genes have an important role in spermatogenesis process and fertility of male mice. but the potential role of these genes in human spermatogenesis and fertility is not known yet. therefore, we evaluated expression ratios of these genes in testis tissues of men with normal and impaired spermatogenesis. materials and methods: in this...

OBJECTIVE Animal model studies have shown that MSY2 and JHDM2A genes have an important role in spermatogenesis process and fertility of male mice. But the potential role of these genes in human spermatogenesis and fertility is not known yet. Therefore, we evaluated expression ratios of these genes in testis tissues of men with normal and impaired spermatogenesis. MATERIALS AND METHODS In this...

Fragments of testis tissue from immature animals grow and develop spermatogenesis when grafted onto subcutaneous areas of immunodeficient mice. The same results are obtained when dissociated cells from immature testes of rodents are injected into the subcutis of nude mice. Those cells reconstitute seminiferous tubules and facilitate spermatogenesis. We compared these two methods, tissue graftin...

Spermatogenesis, the formation of sperm, is a complex developmental process that begins with the mitotic proliferation of spermatogonia and proceeds through extensive morphological changes that convert the haploid spermatid into a mature, functional spermatozoon. Although the process of spermatogenesis is the same in both mammalian and nonmammalian vertebrates, its control mechanisms are not we...

this study was designed to clarify bilaterally effect of long-time varicocele on left and right testes and to identify the effect of varicocele on maturation divisions during spermatogenesis. moreover, the percentage of seminiferous tubules (sts) with i-viii and ix-xiv stages of spermatogenesis and sperm parameters such as sperm motility and abnormality types were evaluated. the left varicocele...

Abstract Study question Does IGF2BP3 regulate Tcf4 mRNA stability in an N6-methyladenosine (m6A)-dependent manner, affect spermatogenesis, and lead to idiopathic non-obstructive azoospermia (iNOA)? Summary answer induces apoptosis of spermatogenic cells by regulating the m6A-dependent which turn affects spermatogenesis leading iNOA. What is known already Azoospermia most serious phenotype male ...

The effect of 3 months exposure to short day length (L:D, 9:15) on spermatogenesis in R. cyanophlyctis was studied. There was no difference in the qualitative and quantitative aspect of spermatogenesis between control frogs exposed to ambient photoperiod (L:D, 12.16:11.44) and frogs exposed to short day light. The present findings indicate that light has no role in spermatogenesis in the frog.