Diversity-directed synthesis based on the cascade allylation chemistry of indigo, with its embedded 2,2'-diindolic core, has resulted in rapid access to new examples of the hydroxy-8a,13-dihydroazepino[1,2-a:3,4-b']diindol-14(8H)-one skeleton in up to 51% yield. Additionally a derivative of the novel bridged heterocycle 7,8-dihydro-6H-6,8a-epoxyazepino[1,2-a:3,4-b']diindol-14(13H)-one was produ...

Infections are one of the most important causes of death, disability and inappropriate conditions for millions of people around the world. Therefore, the development in prognosis, prevention and treatment of infectious diseases made a considerable progress in designing and synthesis of new antimicrobial drugs. Nowadays, due to the increase in microbial resistance, discovery of new compounds wit...

accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...

1,3-Dihydro-1,3,3-trimethyl-8'-nitro-spiro[2H-indole-2,3'-[3H]naphth[2,1-b][1,4]oxazine] (SpO) is a photochromic, acidichromic and metallochromic compound. Its chromogenic properties are characterized in acetonitrile, at room temperature. They are exploited to process both boolean and Fuzzy logic. By using HClO(4), AlCl(3) and Cu(ClO(4))(2) as chemical inputs, UV radiation as power supply, and ...

widely in Xinjiang Uygur Autonomous Region and Tibet of China. Its root barks, leaves and fruits are used for the treatment of rheumatism in traditional medicine. Previous investigations have led to the isolation of different chemical components showing various bioactivities from the Capparis genus while up to now, there is no report regarding chemical constituents of this species. In the prese...

Heterocyclic compounds containing β-lactum structure with different hetero atoms are found to show biological activities1. In the present work, it has been synthesized the semicarbozone and thiosemicarbozone derivatives of 3-methyl-2,6-diphenylpiperidin-4-one followed bycyclisation to get the spiro compounds. These spiro compounds. The spiro products have been characterized by C,H,M analysis, I...