abstract  introduction: diabetes mellitus is the most common metabolic and endocrine disease. depressed heart rate variability (hrv) is an early warning sign of diabetic neuropathy. in numerous studies, spironolactone improved hrv and decreased mortality in congestive heart failure (chf). this study was performed to assess the effect of spironolactone on hrv in diabetic patients. methods: this ...

This case indicates that synergism may occur between lithium and spironolactone, which might be clinically useful in patients resistant to lithium or in whom low dose lithium is advisable. Moreover, this case also indicates that spironolactone alone may maintain a manic patient in remission. Further research is needed to assess the mode of action of spironolactone alone or in combination with l...

BACKGROUND While there is an evidence that the anti-inflammatory properties of spironolactone can attenuate proteinuria in type 2 diabetes, its effects on vascular endothelial growth factor (VEGF) expression in diabetic nephropathy have not been clearly defined. In this study, we examined the effects of spironolactone, losartan, and a combination of these two drugs on albuminuria, renal VEGF ex...

Women are especially predisposed to development of arterial stiffening secondary to obesity because of consumption of excessive calories. Enhanced activation of vascular mineralocorticoid receptors impairs insulin signaling, induces oxidative stress, inflammation, and maladaptive immune responses. We tested whether a subpressor dose of mineralocorticoid receptor antagonist, spironolactone (1 mg...

OBJECTIVE To determine the safety of spironolactone prescribing in the setting of the UK National Health Service. DESIGN Population based longitudinal analysis using a record linkage database. SETTING Tayside, Scotland. Population All patients who received one or more dispensed prescriptions for spironolactone between 1994 and 2007. MAIN OUTCOME MEASURES Rates of prescribing for spironola...

BACKGROUND Previous studies have suggested that aldosterone blockade can reduce the incidence of ventricular tachycardia (VT) or ventricular fibrillation (VF) in patients with heart failure. The SPIronolactone to Reduce ICD Therapy (SPIRIT) trial was designed to test the hypothesis that spironolactone reduces the incidence of VT/VF in patients with implantable cardioverter-defibrillators (ICDs)...

This study tests the hypothesis that spironolactone influences plasminogen activator inhibitor-1 (PAI-1) concentrations through mineralocorticoid receptor antagonism rather than through changes in potassium. Effects of spironolactone (50 mg per day) and triamterene (50 mg per day) on fibrinolytic balance were compared in 18 normotensive and 20 hypertensive subjects pretreated with hydrochloroth...

INTRODUCTION AND OBJECTIVES The aim of this study was to evaluate the use of spironolactone and doxazosin as treatment for patients with resistant hypertension. METHODS This retrospective study involved 181 outpatients with resistant hypertension (defined as a failure of blood pressure [BP] control despite treatment with three drugs, one of which was a diuretic) who received additional spiron...

Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function was investigated in type 2 diabetic rats. For define the molecular mechanism of spironolactone, the effect of spironolactone on the synthesis of monocyte chemotactic peptide-1 (MCP-1) and its upstream transcription...

Over the past 20 years, attention to the renin-angiotensinaldosterone system has brought marked success in the treatment of heart failure (HF). With the publication of the Randomized Aldactone Evaluation Study (RALES) trial, spironolactone became another cornerstone of therapy for the treatment of patients with New York Heart Association (NYHA) functional class III to IV HF (1). Based on the st...