In this paper, a new logistics model is proposed for delivery of prioritized items in disaster relief operations. It considers multi-items, multi-vehicles, multi-periods, soft time windows, and a split delivery strategy scenario, and is formulated as a multiobjective integer programming model. To effectively solve this model we need to limit the number of available tours. Two heuristic approach...

SETTING In most developing countries, paediatric tuberculosis is treated with split tablets leading to potential inaccuracy in the dose delivery and drug exposure. There is no data on the quality of first-line drugs content in split fixed-dose combination tablets. OBJECTIVE To determine Isoniazid, Pyrazinamide and Rifampicin content uniformity in split FDC tablets used in the treatment of chi...

The min-max Split Delivery Multi-Depot Vehicle Routing Problem with Minimum Service Time Requirement (min-max SDMDVRP-MSTR) is a variant of the Multi-Depot Vehicle Routing Problem. Each customer requires a specified amount of service time. The service time can be split among vehicles as long as each vehicle spends a minimum amount of service time at a customer. The objective is to minimize the ...

This paper concerns the Split Delivery Vehicle Routing Problem (SDVRP). This problem is a relaxation of the Capacitated Vehicle Routing Problem (CVRP) since the customers’ demands are allowed to be split. We deal with the cases where the fleet is unlimited (SDVRP-UF) and limited (SDVRP-LF). In order to solve them, we implemented a multi-start Iterated Local Search (ILS) based heuristic that inc...

Programmable and precise regulation of dCas9 functions in response to multiple molecular signals by using synthetic gene circuits will expand the application of the CRISPR-Cas technology. However, the application of CRISPR-Cas therapeutic circuits is still challenging due to the restrictive cargo size of existing viral delivery vehicles. Here, we construct logic AND circuits by integrating mult...