We have characterized the posttranslational methylation of Rps2, Rps3, and Rps27a, three small ribosomal subunit proteins in the yeast Saccharomyces cerevisiae, using mass spectrometry and amino acid analysis. We found that Rps2 is substoichiometrically modified at arginine-10 by the Rmt1 methyltransferase. We demonstrated that Rps3 is stoichiometrically modified by ω-monomethylation at arginin...

WHATSON, T. S., J. L. SMART AND J. DOBBING. Dominance relationships among previously undernourished and well fed male rats. PHYSIOL. BEHAV. 14(4)425-429, 1975. Experimental rats were growth retarded by underfeeding their mothers during pregnancy and lactation. All rats were fed ad lib from weaning. Pairs of previously undernourished (PU) and control (C) males were housed together from 30 or 80 ...

Transfer RNA (tRNA) methylation is necessary for the proper biological function of tRNA. The N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which is widely identified in eukaryotes and archaea, was found to be catalyzed by the Trm10 family of methyltransferases (MTases). Here, we report the first crystal structures of the tRNA MTase spTrm10 from Schizosaccharomyces pombe in the pre...

background: isolated right bundle branch block (rbbb) is a common finding in the general population. the atrioventricular node (avn) artery contributes to the blood supply of the right bundle branch. our hypothesis was that the anatomy of the avn artery and the pattern of dominancy differ between subjects with and without rbbb. methods: w e retrospectively studied the coronary angiography of 92...

iatrogenic coronary artery dissection during coronary angiography with or without rupture is a rare but feared complication . we herein report a case of iatrogenic left main coronary artery dissection in a 49-year-old female. admitted to our hospital with a recent history of severe hypotension, she develpled apnea during angiography. she was intubated  and resuscitated with an epinephrine infus...

a 48-year-old woman was admitted to the emergency department with complaints of typical chest pain, cold sweat, and dyspnea of 24 hours’ duration. she had a history of hypertension, hyperlipidemia, and diabetes mellitus for many years. on admission, her electrocardiogram (ecg) revealed normal sinus rhythm and dynamic t inversion in the precordial leads. her enzyme levels were normal. transthora...

Licking behavior in rodents is widely used to determine fluid consumption in various behavioral contexts and is a typical example of rhythmic movement controlled by internal pattern-generating mechanisms. The measurement of licking behavior by commercially available instruments is based on either tongue protrusion interrupting a light beam or on an electrical signal generated by the tongue touc...

The neuroscience of flavor perception is becoming increasingly important to understand abnormal feeding behaviors and associated chronic diseases such as obesity. Yet, flavor research has mainly depended on human subjects due to the lack of an animal model. A crucial step towards establishing an animal model of flavor research is to determine whether the animal uses the retronasal mode of olfac...

Ribosome biogenesis in eukaryotes requires the participation of a large number of ribosome assembly factors. The highly conserved eukaryotic nucleolar protein Nep1 has an essential but unknown function in 18S rRNA processing and ribosome biogenesis. In Saccharomyces cerevisiae the malfunction of a temperature-sensitive Nep1 protein (nep1-1(ts)) was suppressed by the addition of S-adenosylmethio...