In intact cats, morphine hydrochloride (2.0 mg/kg, i.v.) depressed spontaneous discharge of the Purkinje cell in 8 of the 15 neurons tested. These effects of morphine were antagonized by naloxone hydrochloride (0.4 mg/kg, i.v.). This opiate significantly decreased the evoked potentials produced by superficial radial nerve (SR) stimulation in the molecular layer of the cerebellar cortex. Althoug...

Many complex tasks require us to flexibly switch between behavioral rules, associations, and strategies. The prefrontal cerebral cortex is thought to be critical to the performance of such behaviors, although the relative contribution of different components of this structure and associated subcortical regions are not fully understood. We used functional magnetic resonance imaging to measure br...

The pre-Bötzinger complex (preBötC) underlies inspiratory rhythm generation. As a result of network interactions, preBötC neurons burst synchronously to produce rhythmic premotor inspiratory activity. Each inspiratory burst consists of action potentials (APs) on top of a 10- to 20-mV synchronous depolarization lasting 0.3-0.8 s known as inspiratory drive potential. The mechanisms underlying the...

The present study was conducted to determine the effects of administration of centrally active antitussive drugs on the cough motor pattern. Electromyograms of diaphragm and rectus abdominis muscles were recorded in anesthetized, spontaneously breathing cats. Cough was produced by mechanical stimulation of the intrathoracic trachea. Centrally acting drugs administered included codeine, morphine...

INTRODUCTION Most patients with multiple sclerosis (MS) experience walking impairment during the course of their disease. From an MS patient’s perspective, walking ability is the most important bodily function. Currently, sustained-release oral fampridine (fampridine-SR) is the only drug approved for the symptomatic treatment of walking disability due to MS. Fampridine is a potassium channel bl...

Switched Reluctance (SR) Motor Drive is of great topical interest. It has the potential lo emerge as a viable option for variable speed applications. Though simple in construction, the motor is quite rugged, and has many attractive /eatures like high torque-to-inertia ratio, fault tolerance, and high eficiency. A number of converter topologies are prescribed for driving the motor. However, its ...

1. Adwani S, Yadav R, Kumar K, Chandra SR, Pal PK. Neuropsychological profile in early Parkinson’s disease: Comparison between patients with right side onset versus left side onset of motor symptoms. Ann Indian Acad Neurol 2016;19:74-8. 2. van der Hoorn A, Bartels AL, Leenders KL, de Jong BM. Handedness and dominant side of symptoms in Parkinson’s disease. Parkinsonism Relat Disord 2011;17:58-6...

This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years) or amateur level (n=20; mean age 48.4±6.9 years), and had sustained on averag...

This paper deals with electromagnetic design and 2-D (two-dimensional) magnetic field analysis of novel low force ripple linear switched reluctance (LSR) motor. The configuration that has been presented here has a higher number of rotor poles than stator poles, and the purpose of this configuration is to improve the force ripple, which is the weak point of LSRMs. In order to illustrate the ...